Cholesterol

A study in *Nature Human Behavior* links an active social life to improved health, identifying specific blood proteins related to social isolation and loneliness. These proteins affect immune response, stress regulation, and risk of diseases like heart disease and diabetes, underscoring the health benefits of social connections.

A study in *Nature Human Behavior* links an active social life to improved immune system function and reduced risk of diseases like heart disease, stroke, and diabetes. Researchers identified specific blood proteins associated with social isolation and loneliness, highlighting their role in health risks and the importance of social relationships for well-being.

Leishmaniasis, caused by Leishmania parasites, challenges global health with current treatments facing resistance, toxicity, and efficacy issues. Key drugs include pentavalent antimonials, amphotericin B, miltefosine, paromomycin, and pentamidine, each with limitations. Novel strategies like combination therapies, advanced drug delivery systems, and immunomodulatory approaches are crucial for overcoming these challenges and reducing the disease's global burden.

The article reviews studies on statin use and its impact on cancer outcomes, including recurrence, mortality, and survival rates across various cancer types. It highlights the potential benefits of statins in cancer therapy and prevention, emphasizing the need for further research to understand their role fully.

The PREVENT calculator, updated by the American Heart Association, now includes heart failure risk estimation, identifying 15 million Americans at high risk, with 4.3 million unlikely to develop other heart diseases. It uses data from primary care visits, offering a new approach to early detection and prevention without extensive testing.

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Researchers used stem cells from PMS patients to study how increased cholesterol production damages nerves, finding that a cholesterol-lowering drug, simvastatin, could mitigate these effects, suggesting a potential new treatment for PMS.

Budget cuts have shifted nutrition research funding from government to private industries, leading to biases. Primary research, traditionally NIH-funded, is now less common. Applied research, often funded by pharma and food industries, can justify supplements or show harm in certain foods. Public health research, ideally government-funded, also sees private industry involvement. Clinical research, primarily pharma-funded, tests medications with variability complicating results. Pharmacological research focuses on managing health markers for long-term profitability. Bias in research includes funding bias, myth bias, scholarly pride bias, publication bias, media bias, government bias, and other conflicts of interest. Understanding these biases is crucial for scrutinizing research conclusions.

Vitamin D3-loaded ethosomes were prepared using a cold technique with varying soya lecithin concentrations, achieving high entrapment efficiency. The optimal formulation, ED3-7, showed significant drug entrapment and controlled release. Ethosomes demonstrated high skin permeability and were non-irritating to rabbit skin, indicating potential for transdermal delivery.

WACKER and CordenPharma secured pandemic-preparedness contracts in 2022 to produce mRNA vaccines in Germany, covering the entire process chain from plasmid DNA to sterile filling. They aim to be fully operational by Q2 2024, with a capacity to produce 80 million vaccine units annually. The project involves significant expansion at WACKER's Halle site and CordenPharma's sites in Frankfurt, Chenôve, and Caponago. Both companies emphasize flexibility and readiness, with a focus on rapid deployment and maintaining standby capacity for vaccine production.