Dexpanthenol (DB09357): A Comprehensive Monograph on its Pharmacological Profile, Clinical Applications, and Therapeutic Potential

1.0 Abstract

Dexpanthenol, the biologically active alcohol analog of D-pantothenic acid, functions as a provitamin of B5. Its therapeutic utility is fundamentally derived from its role as a metabolic precursor to Coenzyme A (CoA), a pivotal molecule in numerous cellular processes. This monograph provides a comprehensive analysis of Dexpanthenol, consolidating data from chemical, pharmacological, and clinical domains. The molecule's central mechanism involves its intracellular conversion to pantothenic acid, which is subsequently integrated into the structure of CoA. This single biochemical event underpins its dual, seemingly disparate, therapeutic applications. Systemically, administered via injection, Dexpanthenol acts as a cholinergic agent to stimulate gastrointestinal motility, serving as a critical intervention for the prevention and treatment of postoperative paralytic ileus. Topically, it is a ubiquitous ingredient in dermatological and cosmetic formulations, where it functions as a potent humectant, an enhancer of skin barrier function, and a promoter of epithelial regeneration and wound healing. Its efficacy in these areas is supported by its ability to stimulate fibroblast proliferation, accelerate re-epithelialization, and modulate the expression of genes integral to the healing process. The safety profile of Dexpanthenol is exceptionally favorable, with adverse events being rare and typically mild, although a clinically significant drug interaction with succinylcholine is noted for the injectable form. While it has a long history of clinical use, recent research continues to uncover novel applications in areas such as ophthalmology, hair loss, and microbiome-supportive skincare. This report synthesizes the extensive body of knowledge on Dexpanthenol, establishing it as a venerable yet continually evolving therapeutic agent with significant and expanding clinical relevance.

2.0 Chemical Identity and Physicochemical Properties

A precise understanding of the chemical and physical nature of Dexpanthenol is foundational to appreciating its formulation, biological activity, and therapeutic applications. This section delineates its nomenclature, molecular structure, and key physicochemical characteristics.

2.1 Nomenclature and Standardized Identifiers

Dexpanthenol is identified by a variety of names and standardized codes across chemical, pharmaceutical, and regulatory databases. This multiplicity of identifiers necessitates a consolidated reference to ensure clarity and facilitate cross-disciplinary research. Its primary generic name is Dexpanthenol, while it is also commonly referred to as D-Panthenol.[1] The International Union of Pure and Applied Chemistry (IUPAC) designates its systematic name as

(2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide.[3] An extensive list of synonyms exists, reflecting its long history of use and widespread commercialization, including terms such as (+)-Panthenol, D-Pantothenol, D-Pantothenyl alcohol, Provitamin B5, and various trade names like Bepanthen, Ilopan, and Panthoderm.[1] To provide a definitive reference, these identifiers are consolidated in Table 1.

Table 1: Chemical and Pharmacological Identifiers for Dexpanthenol

Category	Identifier Type	Identifier	Source/System
Drug Identity	Generic Name	Dexpanthenol	N/A
	DrugBank ID	DB09357	DrugBank
	Type	Small Molecule	DrugBank
Chemical Names	IUPAC Name	(2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide	IUPAC
	Systematic Name	D-(+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethybutylamide	N/A
Registry Numbers	CAS Number	81-13-0	Chemical Abstracts Service
	UNII	1O6C93RI7Z	FDA Global Substance Registration System (GSRS)
	EC Number	201-327-3	European Community
Pharmacological Codes	ATC Code	A11HA30 (Alimentary tract and metabolism)	WHO
	ATC Code	D03AX03 (Dermatologicals)	WHO
	ATC Code	S01XA12 (Sensory organs)	WHO
Structural Codes	SMILES	CC(C)(CO)[C@H](C(=O)NCCCO)O	Simplified Molecular-Input Line-Entry System
	InChIKey	SNPLKNRPJHDVJA-ZETCQYMHSA-N	IUPAC International Chemical Identifier
Selected Synonyms	Common Names	D-Panthenol, D-Pantothenol, D(+)-Panthenol, Provitamin B5	N/A
	Brand Names	Bepanthen, Bepanthene, Ilopan, Panthoderm, Motilyn, Pantol	N/A

2.2 Molecular Structure and Stereoisomerism

Dexpanthenol is a monocarboxylic acid amide with the chemical formula C9​H19​NO4​.[1] It has an average molecular weight of approximately 205.25 g/mol and a monoisotopic mass of 205.131408101 Da.[1] For computational chemistry and database interoperability, its structure is represented by the SMILES string

CC(C)(CO)[C@H](C(=O)NCCCO)O and the InChIKey SNPLKNRPJHDVJA-ZETCQYMHSA-N.[3]

A critical aspect of Dexpanthenol's chemistry is its stereoisomerism. The molecule contains a single chiral center, giving rise to two enantiomers: the dextrorotatory (D) form and the levorotatory (L) form. The term "Panthenol" is often used in commercial and consumer contexts to refer to the racemic mixture (DL-Panthenol), which contains both enantiomers.[1] However, a crucial distinction exists in their biological activity. Only the D-enantiomer, Dexpanthenol, is biologically active.[1] This is because Dexpanthenol is the direct alcoholic precursor to D-pantothenic acid, the naturally occurring form of vitamin B5 that is utilized by biological systems for the synthesis of Coenzyme A.[1] The L-enantiomer, while possessing humectant and moisturizing properties similar to the D-form, cannot be converted to pantothenic acid and therefore does not participate in the critical metabolic pathways that underpin Dexpanthenol's full therapeutic effects, such as cellular regeneration and wound healing.[1] This distinction is of paramount importance for pharmaceutical formulation and clinical application, as the therapeutic efficacy for anything beyond superficial hydration is dependent on the presence and concentration of the D-enantiomer.

2.3 Physical and Chemical Characteristics

The physical properties of Dexpanthenol directly influence its formulation into diverse pharmaceutical and cosmetic products, from sterile injections to topical ointments.

Appearance and Form: Dexpanthenol presents as a clear, colorless to slightly yellow, highly viscous liquid or semi-solid at room temperature.[4] It is notably hygroscopic, meaning it readily attracts and holds water molecules from the surrounding environment.[5] Upon standing, some crystallization may occur.[3] It possesses a slight, characteristic odor and a slightly bitter taste.[3]

Solubility Profile: Its solubility is a key determinant of its versatility. Dexpanthenol is freely soluble in water, alcohol (ethanol), methanol, and propylene glycol. It is slightly soluble in glycerin and moderately soluble in diethyl ether.[3] This broad solubility profile allows for its incorporation into a wide array of vehicles. Its high water solubility enables the creation of aqueous solutions for parenteral administration, while its solubility in glycols and alcohols facilitates its use in lotions, gels, and sprays.

Stability: Dexpanthenol is stable in neutral aqueous solutions. However, it is susceptible to hydrolysis and decomposes rapidly in the presence of strong acids or bases.[13] This chemical instability under pH extremes is a critical consideration for formulators, who must ensure that the final product's pH is maintained within a neutral range to preserve the integrity and efficacy of the active ingredient.

Other Properties: The density of Dexpanthenol is approximately 1.2 g/cm³ at 20°C.[3] Its boiling point is reported as 118-120°C at a pressure of 0.02 mm Hg, though it tends to decompose upon distillation at atmospheric pressure.[3]

The unique combination of these physicochemical properties—high water solubility, hygroscopicity, and broad vehicle compatibility—is directly responsible for Dexpanthenol's widespread use. These characteristics allow it to be formulated as both a systemic agent delivered in an aqueous medium and a topical agent delivered in various emollient bases, enabling effective delivery to diverse biological targets, from the intestinal tract to the stratum corneum.

3.0 Comprehensive Pharmacological Profile

The pharmacological actions of Dexpanthenol are multifaceted, encompassing systemic effects on the gastrointestinal tract and profound local effects on epithelial tissues. All of these actions, however, originate from a single, central metabolic pathway: its conversion into Coenzyme A.

3.1 Mechanism of Action

The mechanism of Dexpanthenol is best understood by examining its transformation within the cell and the subsequent roles of its metabolic product.

3.1.1 The Central Metabolic Pathway: Conversion to Coenzyme A

Upon administration and absorption into cells, Dexpanthenol undergoes rapid enzymatic cleavage to form D-pantothenic acid, also known as vitamin B5.[1] This conversion is the pivotal step that activates the molecule. Pantothenic acid is an essential, and in some cases rate-limiting, component required for the biosynthesis of Coenzyme A (CoA).[1] CoA is a ubiquitous and fundamentally important molecule that functions as a cofactor in a vast number of enzymatic reactions, particularly those involving the transfer of acetyl groups and other acyl groups.[1] By serving as a readily available precursor to pantothenic acid, Dexpanthenol effectively increases the intracellular pool of CoA, thereby supporting and enhancing the metabolic processes that depend on it. This single mechanism unifies its seemingly distinct systemic and topical effects.

3.1.2 Systemic (Cholinergic) Action

The use of Dexpanthenol as a gastrointestinal stimulant is a direct consequence of its role in neurotransmitter synthesis. CoA is an obligatory cofactor for the enzyme choline acetyltransferase.[1] This enzyme catalyzes the final step in the synthesis of acetylcholine, transferring an acetyl group from acetyl-CoA to choline.[1] Acetylcholine is the principal neurotransmitter of the parasympathetic nervous system, which is responsible for stimulating and maintaining normal intestinal tone and peristalsis.[1] In conditions such as postoperative ileus, a decrease in acetylcholine content can lead to reduced peristalsis and intestinal atony.[1] By increasing the availability of CoA, Dexpanthenol is theorized to enhance the rate of acetylcholine synthesis, thereby acting as a cholinergic agent that increases lower intestinal motility and helps restore normal function.[3]

3.1.3 Topical (Dermatological) Action

The widespread application of Dexpanthenol in dermatology stems from its multifaceted effects on skin physiology, all of which are linked to the functions of CoA.

• Cellular Proliferation and Re-epithelialization: Dexpanthenol has been shown in numerous in vitro and in vivo studies to stimulate the proliferation of dermal fibroblasts.[1] These cells are critical for wound healing, as they synthesize collagen, elastin, and other components of the extracellular matrix that form the structural scaffold of the skin. By promoting fibroblast activity, Dexpanthenol accelerates wound closure and tissue regeneration. It also hastens re-epithelialization, the process where keratinocytes migrate to cover a wound surface, which is a key indicator of successful healing.[1] This proliferative effect is likely driven by the increased energy production (ATP synthesis) and membrane component synthesis facilitated by CoA.[13]
• Gene Regulation: Modern molecular analyses have revealed that Dexpanthenol's effects extend to the genetic level. It has been shown to modulate the expression of several genes that are critical for the wound healing cascade.[21] This includes the upregulation of key cytokines such as interleukin-6 (IL-6) and interleukin-8 (IL-8) in dermal fibroblasts.[1] While often associated with inflammation, these cytokines play an essential signaling role in the early phases of wound healing, attracting immune cells and initiating the repair process.
• Barrier Function and Moisturization (Humectant Effect): Dexpanthenol is an exceptionally effective moisturizer due to two synergistic mechanisms. First, as a hygroscopic molecule, it acts as a humectant, directly attracting water from the atmosphere and the deeper layers of the skin and binding it within the stratum corneum, thereby increasing skin hydration.[5] Second, its conversion to CoA supports the synthesis of fatty acids and sphingolipids, which are crucial components of the lamellar lipid bilayers in the stratum corneum.[19] A robust lipid barrier is essential for preventing transepidermal water loss (TEWL). By enhancing both water content and lipid barrier integrity, Dexpanthenol effectively improves skin hydration, softness, and elasticity.
• Anti-inflammatory and Antioxidant Properties: Dexpanthenol exhibits demonstrable anti-inflammatory effects, capable of reducing symptoms like erythema (redness) caused by UV exposure or other irritants.[1] This action is thought to be mediated through the modulation of inflammatory cytokine production.[14] Furthermore, its role as a precursor to CoA provides an antioxidant benefit. CoA is involved in metabolic pathways that can increase the cellular content of glutathione, one of the body's most important endogenous antioxidants, thereby protecting cells from damage by reactive oxygen species.[13]

The unifying role of Coenzyme A demonstrates that Dexpanthenol is not a conventional drug that targets a specific receptor but rather a metabolic substrate enhancer. It supports and optimizes fundamental cellular processes, which explains its broad range of applications and its remarkably high safety profile. It works by providing the necessary building blocks for tissue-specific functions, whether it be neurotransmitter synthesis in the gut or lipid and energy synthesis in the skin.

3.2 Pharmacodynamics

The pharmacodynamic effects of Dexpanthenol are the observable physiological consequences of its mechanisms of action.

For systemic administration, the primary pharmacodynamic outcome is the stimulation of gastrointestinal smooth muscle. This manifests as an increase in peristaltic activity and a restoration of normal intestinal tone, providing a therapeutic effect in patients with or at risk of adynamic ileus.[26]

For topical application, the pharmacodynamic effects are diverse and directly beneficial to skin health. As an emollient and moisturizer, it measurably improves skin hydration, reduces TEWL, softens rough skin, and alleviates symptoms such as itching and flaking associated with xerosis.[26] As a skin protectant, it forms a physical barrier that shields the skin from external irritants, such as moisture and enzymes in feces and urine, which is the basis for its use in diaper rash products.[1] Finally, as a cicatrizant, it actively promotes wound healing by stimulating granulation tissue formation and accelerating epithelialization, leading to faster repair of minor burns, abrasions, and other skin lesions.[19]

3.3 Pharmacokinetics (ADME)

The absorption, distribution, metabolism, and excretion (ADME) profile of Dexpanthenol differs based on its route of administration.

Absorption:

• Topical: Dexpanthenol is well-absorbed through the skin and mucous membranes, where it can achieve high local concentrations necessary for its dermatological effects.[1] The formulation vehicle plays a critical role in the extent and rate of penetration. Studies have shown that water-in-oil (W/O) emulsions facilitate significantly greater skin penetration compared to oil-in-water (O/W) formulations.[3] This is a crucial consideration in product design, as the choice of vehicle is not merely cosmetic but a key determinant of the active ingredient's bioavailability and clinical efficacy. A W/O base creates an occlusive film that enhances hydration and drives the active ingredient into the viable epidermis and dermis where it can exert its cellular effects.
• Systemic: When administered via intramuscular (IM) injection, Dexpanthenol is readily absorbed from the injection site.[26] Comprehensive human pharmacokinetic data for parenteral administration are reported to be limited.[15]

Distribution:

Following absorption and its conversion to pantothenic acid, the molecule is widely distributed throughout the body tissues, predominantly in the form of Coenzyme A.3 The highest tissue concentrations are found in metabolically active organs such as the liver, adrenal glands, heart, and kidneys.3

Metabolism:

The metabolism of Dexpanthenol is simple and efficient. It is rapidly converted within cells into its biologically active form, D-pantothenic acid.1 This is the sole and essential metabolic activation step.

Excretion:

The body excretes pantothenic acid primarily via the kidneys, with approximately 70% of an oral dose being eliminated unchanged in the urine. The remaining 30% is excreted in the feces.3 Pantothenic acid is also a normal constituent of human breast milk, with concentrations of about 2 µg/mL in mothers on a normal diet.3

4.0 Clinical Efficacy and Therapeutic Applications

Dexpanthenol's dual utility as a systemic gastrointestinal agent and a topical dermatological product has led to a broad spectrum of clinical applications, ranging from critical care settings to routine over-the-counter skin care.

4.1 Approved and Established Systemic Indications

Administered parenterally (via injection), Dexpanthenol's primary clinical role is in the management of gastrointestinal motility disorders, particularly in the postoperative setting.

• Postoperative Ileus and Intestinal Atony: The principal indication for injectable Dexpanthenol is the prophylactic use immediately after major abdominal surgery to prevent or minimize the possibility of paralytic ileus—a temporary cessation of bowel motility.[1] It is also employed for the treatment of established intestinal atony that results in abdominal distention, postoperative or postpartum retention of flatus, and a general delay in the resumption of normal intestinal function.[1]
• Vitamin Deficiency: Dexpanthenol is an essential component of intravenous multivitamin preparations used in total parenteral nutrition (TPN). Products such as Infuvite and Mvi Pediatric include Dexpanthenol to supply necessary vitamin B5 to patients who are unable to absorb nutrients through the gastrointestinal tract, thereby preventing deficiency.[1]

4.2 Established Dermatological and Mucosal Applications

The most widespread and publicly recognized use of Dexpanthenol is in topical formulations for skin and mucosal health, where it leverages its moisturizing, barrier-repairing, and wound-healing properties.

• General Moisturization and Skin Barrier Support: It is a cornerstone ingredient in products designed to treat and prevent xerosis (dry skin) and its associated symptoms, such as roughness, scaling, and pruritus (itching).[1] Its ability to improve skin barrier function makes it particularly valuable in the management of chronic skin conditions like atopic dermatitis, where a compromised barrier is a key pathological feature.[24]
• Minor Skin Irritations and Wounds: Dexpanthenol is highly effective for a range of common minor skin ailments. It is a standard treatment for irritant diaper dermatitis (nappy rash), where it both soothes irritated skin and forms a protective barrier against moisture and irritants.[1] It is also indicated for the treatment of sunburn, mild burns, and skin burns resulting from radiation therapy.[1]
• Post-Procedure Care: There is a growing body of evidence and clinical practice supporting the use of Dexpanthenol for post-procedural wound care. It is recommended after various medical and cosmetic interventions that disrupt the epidermal barrier, such as dermabrasion, ablative laser resurfacing, chemical peels, microneedling, and tattooing.[1] In this context, it helps to accelerate re-epithelialization, reduce inflammation, minimize the risk of complications, and improve the final aesthetic outcome.
• Mucosal Lesions: Its gentle, regenerative properties make it suitable for application to mucous membranes. It is used in formulations to treat lesions such as aphthous ulcers (canker sores) and to soothe general inflammation of the oral mucosa.[1]

4.3 Use in Combination Formulations

Dexpanthenol is frequently included as a supportive ingredient in multi-component products, where its primary role is to enhance the tolerability of the primary active ingredient or to provide complementary healing benefits. In these formulations, it often functions as a "protective adjuvant," working to maintain the health of the local tissue environment that is being treated.

• Nasal Decongestants: It is combined with vasoconstrictors like xylometazoline in nasal sprays for allergic rhinitis and sinusitis.[1] While xylometazoline reduces congestion, it can also cause dryness and irritation of the nasal mucosa. Dexpanthenol is added to counteract these effects by moisturizing and promoting the healing of the delicate nasal epithelium.
• Topical Anti-inflammatory/Analgesic Gels: In formulations with heparin and dimethyl sulfoxide (DMSO) for treating soft tissue injuries like contusions, bursitis, and edema, Dexpanthenol's role is to support skin health and repair at the site of application.[1]
• Anti-Itch and Insect Bite Relief: Dexpanthenol is formulated alongside local anesthetics (e.g., lidocaine) and antihistamines (e.g., mepyramine) in creams for insect bites.[1] The primary agents provide pain and itch relief, while Dexpanthenol soothes the associated skin irritation and promotes the healing of the bite lesion.
• Sore Throat Lozenges: It is included with antiseptics such as dequalinium for the symptomatic treatment of sore throats and pharyngeal inflammation.[1] Here, it provides a soothing and coating effect on the irritated mucous membranes of the throat.

This consistent pattern of use highlights a key therapeutic principle: Dexpanthenol can be strategically employed to improve the overall performance of other topical drugs by ensuring the local tissue remains hydrated, protected, and capable of efficient repair.

5.0 Analysis of Clinical Trial Evidence

While Dexpanthenol has a long history of empirical use, its efficacy is increasingly being substantiated by formal clinical trials. These studies are not only validating its established roles but also exploring novel therapeutic avenues.

5.1 Review of Completed Clinical Studies

Several clinical trials have been completed across various indications, providing evidence-based support for Dexpanthenol's therapeutic effects. A summary of key completed trials is presented in Table 2.

Table 2: Summary of Key Completed Clinical Trials Involving Dexpanthenol

NCT Identifier	Study Phase	Condition/Indication	Intervention	Status	Key Finding/Purpose
NCT00839280	Phase 2	Skin Abnormalities	Dexpanthenol Formulations	Completed	To assess the moisturizing effect of two different dexpanthenol formulations.34
NCT02794922	Phase 2	Temporomandibular Joint Dysfunction	Vitamin B Complex (incl. Dexpanthenol)	Completed	To evaluate the effectiveness of Vitamin B in reducing pain associated with TMJ disorder.35
NCT01283646	Phase 3	Lack or Loss of Appetite	Vitamin Complex (incl. Dexpanthenol) vs. Vitamin Complex	Completed	To assess the efficacy and tolerability of Apevitin BC in stimulating appetite.36

The Phase 2 trial NCT00839280 provides direct clinical evidence supporting Dexpanthenol's fundamental role as a skin moisturizer, validating its most common application.[34] Beyond dermatology, other studies point to broader systemic effects. A Phase 2 trial (NCT02794922) investigating a vitamin B complex that included Dexpanthenol for temporomandibular joint (TMJ) pain suggests a potential role in managing pain and inflammation, possibly linked to its functions in cellular energy and nerve health.[35] Furthermore, a Phase 3 trial (NCT01283646) successfully demonstrated the efficacy of a vitamin complex containing Dexpanthenol for appetite stimulation, hinting at its influence on systemic metabolism.[36]

5.2 Insights from Recent and Ongoing Research

The landscape of Dexpanthenol research is evolving, with recent and ongoing trials focusing on more specific, often prophylactic, applications in specialized medical fields. This trend marks a maturation in the study of the molecule, moving from confirming its general properties to validating its utility in niche clinical scenarios where tissue damage is a predictable consequence of treatment.

• Ophthalmology (Dry Eye Syndrome): There is significant interest in leveraging Dexpanthenol's epithelial healing properties for the ocular surface. An ongoing, multicenter, non-inferiority clinical investigation (NCT06210373) is actively comparing the efficacy and safety of two different 5% Dexpanthenol eye gel products (Myrialen® and Recugel®) for patients with moderate to severe dry eye syndrome.[37] This indicates a move towards establishing Dexpanthenol as a primary therapeutic agent for ocular surface disorders.
• Post-Surgical Care: A novel application in pediatric surgery was explored in a recently completed study (NCT07002632). This trial investigated the prophylactic use of 5% Dexpanthenol cream to prevent angular cheilitis (lip corner cracks) in children undergoing tonsillectomy or adenoidectomy, a common and uncomfortable side effect of the procedure. This targeted, preventative approach showcases a sophisticated application of its wound-healing properties.[38]
• Aesthetic Dermatology: Reflecting the growth in cosmetic procedures, several completed studies sponsored by Bayer (NCT03853512, NCT03853525) have evaluated the efficacy of a Dexpanthenol dermal spray in promoting skin recovery in the sensitive inguinal and intimate areas following procedures such as chemical peels and laser hair removal.[39] These trials aim to generate high-quality evidence for its use in minimizing downtime and improving outcomes in aesthetic medicine.
• Hair Loss: Moving beyond the skin, a pioneering study has investigated the use of systemic (intramuscular) Dexpanthenol as a novel treatment for female pattern hair loss (FPHL).[42] The study reported high levels of patient satisfaction and a significant improvement in quality of life, with no side effects reported, opening a potentially major new therapeutic avenue for the drug.
• Atopic Dermatitis and the Microbiome: Recent research has focused on the role of Dexpanthenol in managing atopic dermatitis. Clinical studies on Dexpanthenol-containing cleansers and creams have demonstrated not only good tolerability and improved skin hydration but also, critically, no negative impact on the diversity of the skin microbiome.[43] This positions Dexpanthenol as a key ingredient for formulations designed to support a healthy skin barrier while respecting the delicate microbial ecosystem.

This shift in clinical investigation from general to specific applications demonstrates that Dexpanthenol is being progressively positioned as a targeted therapeutic agent. Its value is increasingly seen not just as a treatment for existing skin conditions but as a prophylactic measure to prevent or mitigate the predictable epithelial damage that accompanies a wide range of medical and cosmetic interventions, thereby elevating its clinical standing.

6.0 Safety, Tolerability, and Risk Management

Dexpanthenol is widely regarded as a substance with an exceptionally high safety and tolerability profile, a characteristic that has contributed to its extensive use in both prescription and over-the-counter products for decades.

6.1 Adverse Event Profile

Adverse events associated with Dexpanthenol are infrequent and generally mild, varying slightly with the route of administration.

• Topical Application: When applied to the skin, Dexpanthenol is very well-tolerated by most individuals.[18] The most commonly reported side effects, which are themselves infrequent, consist of mild, localized skin irritation such as a burning or stinging sensation, redness, or itching.[27] A very serious allergic reaction is considered rare.[27] However, there is growing recognition that Dexpanthenol can, in some individuals, cause allergic contact dermatitis (ACD). Some studies suggest that ACD from Dexpanthenol may be more common than previously thought and is potentially overlooked as an allergen in chronic eczema cases.[47]
• Systemic (Injectable) Application: Adverse events following parenteral administration are rare. The available literature contains isolated case reports of various events where a causal relationship to Dexpanthenol is often uncertain.[15] These include allergic reactions (manifesting as itching, rash, urticaria, or difficulty breathing), a slight decrease in blood pressure, gastrointestinal symptoms (intestinal colic, vomiting, diarrhea), and one report of agitation in an elderly patient.[15]

Overall, the Cosmetic Ingredient Review (CIR) Expert Panel has assessed Panthenol (including Dexpanthenol) and concluded that it is safe as used in cosmetic products, reinforcing its favorable safety profile.[49]

6.2 Contraindications and Precautions

Despite its high safety profile, there are specific situations where the use of Dexpanthenol is contraindicated or requires special precaution.

• Absolute Contraindications: The primary contraindication for any formulation is a known hypersensitivity (allergy) to Dexpanthenol or any of the excipients in the product.[50] For the injectable form, there are two specific contraindications:

1. Ileus due to mechanical obstruction: Dexpanthenol stimulates peristalsis, which could lead to severe cramping and worsen the condition if a physical blockage is the cause of the ileus.[26]
2. Hemophilia: Due to the risk of bleeding, IM injections should be avoided, and it should not be applied to open wounds in these patients.[26]

• Drug Interactions: The most clinically significant drug interaction involves the injectable form of Dexpanthenol and the neuromuscular blocking agent succinylcholine. Dexpanthenol should not be administered within one hour of succinylcholine, as it has been reported to prolong the latter's neuromuscular blocking effects.[15] This interaction provides strong indirect evidence for Dexpanthenol's systemic mechanism of action. Succinylcholine is an acetylcholine receptor agonist that is degraded by acetylcholinesterase. By increasing the synthesis of acetylcholine, Dexpanthenol increases the concentration of the natural neurotransmitter at the neuromuscular junction. This increased acetylcholine competes with succinylcholine for degradation by acetylcholinesterase, slowing its breakdown and thereby prolonging its paralytic effect. While some sources note rare allergic reactions during concomitant use with antibiotics, narcotics, or barbiturates, no other significant drug interactions are widely reported.[15]
• General Precautions: All topical products are intended for external use only, and care should be taken to avoid contact with the eyes.[27] If any signs of a hypersensitivity reaction occur following systemic administration, the drug should be discontinued immediately.[15]

6.3 Use in Special Populations

• Pregnancy: The injectable form of Dexpanthenol is classified as FDA Pregnancy Category C. This designation indicates that animal reproduction studies have not been conducted, and the drug should be administered to a pregnant woman only if the potential benefit justifies the potential risk to the fetus.[15] In contrast, topical Dexpanthenol is generally considered safe for use during pregnancy and is often used to help manage skin changes like stretch marks.[51] The recommended daily dietary intake of pantothenic acid for pregnant women is 6 mg.[56]
• Lactation: It is not known whether Dexpanthenol is excreted in human milk following parenteral administration; therefore, caution should be exercised.[15] Topical application is considered safe during lactation. For nursing mothers using Dexpanthenol ointment for sore or cracked nipples, it is recommended to gently cleanse the nipple area before each feeding.[57] The recommended daily dietary intake for lactating women is 7 mg.[56]
• Pediatrics: Topical Dexpanthenol is well-established as safe and effective for pediatric use, with its application in the prevention and treatment of diaper rash being a primary example.[33] However, the safety and effectiveness of the injectable form have not been established in children.[15]

7.0 Formulations, Dosage, and Global Availability

Dexpanthenol's versatility is reflected in the wide range of pharmaceutical and cosmetic formulations in which it is available, each tailored to a specific route of administration and therapeutic goal.

7.1 Pharmaceutical Formulations

Dexpanthenol is formulated for systemic, topical, and oral use.

• Injectable Solutions: For systemic use, Dexpanthenol is available as a sterile, aqueous solution for intramuscular (IM) or slow intravenous (IV) administration. The most common concentration for treating gastrointestinal atony is 250 mg/mL.[15] It is also included at lower concentrations (e.g., 2 mg/mL to 15 mg/vial) as a component of multivitamin B-complex injections and infusions for parenteral nutrition.[60]
• Topical Preparations: This is the most diverse category. Dexpanthenol is widely available in over-the-counter (OTC) and cosmetic products as creams, ointments, lotions, and gels.[3] The concentration in these topical products is typically 2% or 5%.[26] More specialized formulations include dermal sprays and ophthalmic gels for direct application to the skin or eyes, respectively.[37]
• Oral Supplements: Dexpanthenol itself is not typically administered orally, but its parent compound, pantothenic acid, is a common component of dietary supplements. These are available as standalone tablets or as part of multivitamin or B-complex formulations. Dosages in these supplements can range widely, from the recommended daily allowance of 5-10 mg up to therapeutic doses of 100 mg or higher.[30]

7.2 Dosing and Administration Guidelines

Dosage regimens for Dexpanthenol are specific to the indication and route of administration.

• Systemic (Gastrointestinal Atony):
• Prophylaxis (Post-Surgery): The typical dose is 250 mg to 500 mg administered intramuscularly. This is repeated in two hours, followed by subsequent doses every six hours until the risk of paralytic ileus has passed.[15]
• Treatment (Existing Ileus): The recommended dose is 500 mg IM, repeated in two hours, and then every six hours as needed to restore motility.[15]
• Intravenous Administration: For patients where IM injection is not suitable, a 500 mg (2 mL) dose may be diluted in a larger volume of standard IV solutions, such as Dextrose 5% in Water (D5W) or Lactated Ringer's solution, and administered as a slow IV infusion.[15]
• Topical (Dermatoses):
• For general skin conditions like dryness or minor irritations, a thin layer of cream or ointment is applied to the affected area once or twice daily, or more frequently as needed.[26]
• For the prevention and treatment of diaper rash, the ointment should be applied liberally to the baby's clean, dry bottom with each diaper change, especially at bedtime.[58]
• Oral Supplementation (as Pantothenic Acid):
• The U.S. Recommended Daily Allowance (RDA) for adults is 5 mg. This increases to 6 mg per day during pregnancy and 7 mg per day during lactation.[30]
• Higher doses have been investigated for specific conditions; for example, studies on dyslipidemia have used the related compound pantethine at doses of 600-900 mg per day.[30]

7.3 Commercial Landscape and Brand Names

Dexpanthenol is marketed globally under numerous brand names, which can vary significantly by region. This can create confusion, as the same active ingredient is known by different names in different markets. Table 3 provides a summary of major brand names in the United States and Europe to clarify its commercial identity.

Table 3: Selected Global Brand Names and Formulations for Dexpanthenol

Region	Brand Name(s)	Formulation(s)	Primary Indication(s)
United States	Ilopan, Dexol	Injection (Systemic)	Gastrointestinal Stimulant
	Panthoderm	Cream (Topical)	Dermatological Agent (Dermatoses, Itching)
	Ilopan Choline	Injection (Systemic, Combination)	Gastrointestinal Stimulant
Europe / Global	Bepanthen, Bepanthene, Bepantol	Ointment, Cream, Lotion (Topical)	Dermatological Agent (Wound Healing, Diaper Rash, Moisturizing)

In the United States, the injectable form is primarily known by the brand name Ilopan, while the main topical brand is Panthoderm.[6] In contrast, across Europe and many other parts of the world, Dexpanthenol is almost synonymous with the brand Bepanthen, which is a market leader for topical products aimed at diaper care, wound healing, and general skin moisturization.[4]

8.0 Regulatory Status and Future Outlook

Despite its long history of use, Dexpanthenol continues to be a subject of regulatory oversight and active research, pointing toward both a stable presence in the current market and a promising future with new applications.

8.1 Global Regulatory Approvals

The regulatory status of Dexpanthenol varies by formulation and region.

• FDA (United States): Dexpanthenol holds a somewhat complex regulatory status in the U.S. It is an officially approved ingredient in several prescription multivitamin infusion products, such as INFUVITE and MVI ADULT, which are administered under medical supervision.[62] However, the standalone Dexpanthenol injection (250 mg/mL) used for gastrointestinal atony is listed in FDA databases under the marketing category "Unapproved drug other".[15] This suggests that it is marketed without a formal New Drug Application (NDA), likely as a "grandfathered" drug that was on the market before the FDA's efficacy requirements were established, or under the agency's enforcement discretion. In contrast, topical preparations containing Dexpanthenol are widely available over-the-counter (OTC) for dermatological use and are considered safe and effective for their labeled indications.[71]
• EMA (Europe): In the European Union, Dexpanthenol is a well-established active substance. It is authorized in numerous nationally approved medicinal products across member states.[73] As an established substance, it is subject to ongoing pharmacovigilance through the European Medicines Agency's Periodic Safety Update Report (PSUR) Single Assessment (PSUSA) procedure (PSUSA/00000999/202401) to continuously monitor its safety profile.[73] Regulatory filings for new combination products or new indications are subject to significant scrutiny. For instance, an application for a combination nasal spray of xylometazoline and dexpanthenol based on "well-established use" faced challenges from regulators, who required more substantial evidence to support the novel claims of better tolerability and shorter treatment duration.[74]

8.2 Emerging Therapeutic Frontiers

Dexpanthenol is a classic example of an "old drug" for which modern scientific tools are revealing "new tricks." Research is actively expanding its therapeutic horizons beyond its traditional uses, driven by a deeper understanding of its molecular mechanisms.

• Hair and Scalp Health: Emerging research is providing a molecular basis for Dexpanthenol's long-standing inclusion in hair care products. Recent studies have demonstrated that Dexpanthenol can promote the growth of cultured human hair follicle cells by preventing cellular senescence and apoptosis (programmed cell death).[75] Furthermore, a clinical study on the systemic (intramuscular) administration of Dexpanthenol for female pattern hair loss showed promising results, with high patient satisfaction and improved quality of life, suggesting a potential new therapeutic indication.[42]
• Ophthalmology: The proven ability of Dexpanthenol to heal epithelial tissues is being actively translated to the treatment of ocular surface diseases. Its hygroscopic and regenerative properties make it an ideal candidate for managing dry eye syndrome, a highly prevalent condition. Ongoing clinical trials are evaluating new ophthalmic gel formulations, which could establish Dexpanthenol as a mainstream treatment in ophthalmology.[13]
• Microbiome Support: With the growing understanding of the skin microbiome's importance in skin health, Dexpanthenol is being positioned as a microbiome-friendly ingredient. Recent studies on cleansers and creams for atopic-prone skin have shown that Dexpanthenol-containing formulations can improve hydration and barrier function without disrupting the natural balance of the skin's microbial community. This aligns with modern dermatological approaches that seek to restore both the physical and biological barriers of the skin.[44]
• Advanced Wound Healing: While well-established for minor wounds, preclinical research is exploring Dexpanthenol's potential in more complex healing scenarios. For example, studies in animal models have suggested that its antioxidant and regenerative properties may positively influence the healing of colonic anastomoses after surgery, potentially reducing complications.[76]

This reinvestigation of a well-established, safe molecule with modern tools like gene expression profiling and microbiome analysis represents a low-risk, high-reward paradigm for pharmaceutical research. It suggests that other "old" vitamins and metabolic precursors may be prime candidates for similar exploration, potentially unlocking new therapeutic uses for trusted compounds.

8.3 Concluding Analysis and Recommendations

Dexpanthenol stands out as a remarkably versatile and safe therapeutic agent. Its diverse clinical applications in gastroenterology, dermatology, and emerging fields are not disparate phenomena but are logically and elegantly unified by its single, fundamental biochemical role as a precursor to Coenzyme A. This function as a metabolic substrate enhancer, rather than a traditional receptor-targeting drug, underpins its broad efficacy and exceptional safety profile. It has firmly established its value as a systemic agent for managing postoperative intestinal atony and as a ubiquitous topical agent for skin protection, moisturization, and wound healing.

Based on the comprehensive analysis of the available evidence, the following recommendations for future research are proposed:

1. Elucidation of Molecular Mechanisms: Further studies employing transcriptomics and proteomics should be conducted to fully map the gene and protein expression changes induced by Dexpanthenol in various cell types (e.g., keratinocytes, fibroblasts, neurons). This will provide a more granular understanding of its regenerative and signaling effects.
2. Large-Scale Clinical Trials for Emerging Applications: The promising preliminary results in female pattern hair loss and dry eye syndrome warrant larger, randomized, placebo-controlled clinical trials to definitively establish efficacy, optimize dosing regimens, and support regulatory submissions for these new indications.
3. Exploration of Novel Delivery Systems: Research into advanced delivery systems, such as nanoparticle-based formulations or drug-eluting contact lenses, could further enhance the bioavailability and targeted delivery of Dexpanthenol to specific tissues like the hair follicle or the ocular surface, thereby optimizing its therapeutic potential.

In conclusion, Dexpanthenol, despite its discovery and use for over 70 years, remains a highly relevant and dynamic molecule. Its foundation as a key metabolic precursor, combined with an outstanding safety profile, ensures its continued place in therapy while simultaneously making it an exciting candidate for continued scientific investigation and future clinical innovation.

Works cited

1. Dexpanthenol: Uses, Interactions, Mechanism of Action | DrugBank Online, accessed September 13, 2025, https://go.drugbank.com/drugs/DB09357
2. Chemical Substance - Dexpanthenol, accessed September 13, 2025, https://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredReq?id=2955
3. Dexpanthenol | C9H19NO4 | CID 131204 - PubChem, accessed September 13, 2025, https://pubchem.ncbi.nlm.nih.gov/compound/Dexpanthenol
4. Panthenol - Wikipedia, accessed September 13, 2025, https://en.wikipedia.org/wiki/Panthenol
5. Dexpanthenol | 81-13-0 - ChemicalBook, accessed September 13, 2025, https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3169304.htm
6. Definition of dexpanthenol cream - NCI Drug Dictionary, accessed September 13, 2025, https://www.cancer.gov/publications/dictionaries/cancer-drug/def/dexpanthenol
7. dexpanthenol, accessed September 13, 2025, https://precision.fda.gov/uniisearch/srs/unii/1o6c93ri7z
8. DEXPANTHENOL USP - PCCA, accessed September 13, 2025, https://www.pccarx.com/products/DEXPANTHENOLUSP/30-2324/APIS-EXCIPIENTS
9. Dexpanthenol | 81-13-0 | FD34938 - Biosynth, accessed September 13, 2025, https://www.biosynth.com/p/FD34938/81-13-0-dexpanthenol
10. Panthenol: Uses, Interactions, Mechanism of Action | DrugBank Online, accessed September 13, 2025, https://go.drugbank.com/drugs/DB11204
11. Dexpanthenol - Safety Data Sheet - ChemicalBook, accessed September 13, 2025, https://www.chemicalbook.com/msds/dexpanthenol.pdf
12. Panthenol - The Cosmetic Chemist, accessed September 13, 2025, http://www.thecosmeticchemist.com/molecule_of_the_week/panthenol.html
13. Brief Communication: Dexpanthenol and Its Ophthalmic Uses - Longdom Publishing, accessed September 13, 2025, https://www.longdom.org/open-access/brief-communication-dexpanthenol-and-its-ophthalmic-uses-51892.html
14. What is the mechanism of Dexpanthenol? - Patsnap Synapse, accessed September 13, 2025, https://synapse.patsnap.com/article/what-is-the-mechanism-of-dexpanthenol
15. Dexpanthenol: Package Insert / Prescribing Information - Drugs.com, accessed September 13, 2025, https://www.drugs.com/pro/dexpanthenol.html
16. www.cancer.gov, accessed September 13, 2025, https://www.cancer.gov/publications/dictionaries/cancer-drug/def/dexpanthenol#:~:text=Although%20the%20exact%20mechanism%20of,itching%20and%20to%20promote%20healing.
17. Dexpanthenol - OEL Fastrac with ADE - Affygility Solutions, accessed September 13, 2025, https://affygility.com/oel/dexpanthenol.html
18. Vitamin B5 (Pantothenic Acid/Dexpanthenol) | Cosmeceuticals and Cosmetic Ingredients | AccessDermatologyDxRx, accessed September 13, 2025, https://dermatology.mhmedical.com/content.aspx?bookid=2812§ionid=244978690
19. (PDF) Pharmacological Effects of Dexpanthenol - ResearchGate, accessed September 13, 2025, https://www.researchgate.net/publication/382529304_Pharmacological_Effects_of_Dexpanthenol
20. Dexpanthenol in Wound Healing after Medical and Cosmetic Interventions (Postprocedure Wound Healing) - MDPI, accessed September 13, 2025, https://www.mdpi.com/1424-8247/13/7/138
21. Dexpanthenol in Wound Healing after Medical and Cosmetic Interventions (Postprocedure Wound Healing) - PMC, accessed September 13, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC7407203/
22. Topical use of dexpanthenol: a 70th anniversary article - PubMed, accessed September 13, 2025, https://pubmed.ncbi.nlm.nih.gov/28503966/
23. Wound healing || Cell proliferation || Gene expression | Study 13069 - Bayer Clinical Trials, accessed September 13, 2025, https://clinicaltrials.bayer.com/study/13069
24. Use of Dexpanthenol for Atopic Dermatitis—Benefits and Recommendations Based on Current Evidence - PMC, accessed September 13, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC9322723/
25. How dexpanthenol helps soothe your skin, accessed September 13, 2025, https://support.withagency.com/en_us/how-dexpanthenol-helps-soothe-your-skin-r1iRmnOnu
26. dexpanthenol, accessed September 13, 2025, https://www.glowm.com/resources/glowm/cd/pages/drugs/d021.html
27. Dexpanthenol Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing, accessed September 13, 2025, https://www.webmd.com/drugs/2/drug-75143/dexpanthenol-topical/details
28. What is Dexpanthenol? | 5 skincare benefits - NIVEA, accessed September 13, 2025, https://www.nivea.co.uk/advice/skin/dexpanthenol
29. Dexpanthenol: New Insights on Wound Healing, a Review - CABI Digital Library, accessed September 13, 2025, https://www.cabidigitallibrary.org/doi/pdf/10.5555/20230490738
30. Vitamin B5 (Pantothenic Acid) - StatPearls - NCBI Bookshelf, accessed September 13, 2025, https://www.ncbi.nlm.nih.gov/books/NBK563233/
31. www.drugs.com, accessed September 13, 2025, https://www.drugs.com/pro/dexpanthenol.html#:~:text=Indications%20and%20Usage%20for%20Dexpanthenol,of%20intestinal%20motility%3B%20paralytic%20ileus.
32. Dexpanthenol (Dextro-Pantothenyl Alcohol) - Nurse Key, accessed September 13, 2025, https://nursekey.com/dexpanthenol-dextro-pantothenyl-alcohol/
33. New Insights in the Skin Protective Activity of a Dexpanthenol Containing Formula (BEPANTHEN®) in a Diaper Rash-Like Model - Scientific Research Publishing, accessed September 13, 2025, https://www.scirp.org/journal/paperinformation?paperid=100649
34. Dexpanthenol Completed Phase 2 Trials for Skin Abnormalities Treatment - DrugBank, accessed September 13, 2025, https://go.drugbank.com/drugs/DB09357/clinical_trials?conditions=DBCOND0038105&phase=2&purpose=treatment&status=completed
35. Dexpanthenol Completed Phase 2 Trials for Temporomandibular Joint Dysfunction Treatment | DrugBank Online, accessed September 13, 2025, https://go.drugbank.com/drugs/DB09357/clinical_trials?conditions=DBCOND0039544&phase=2&purpose=treatment&status=completed
36. Dexpanthenol Completed Phase 3 Trials for Lack or Loss Appetite Nonorganic Origin Treatment | DrugBank Online, accessed September 13, 2025, https://go.drugbank.com/drugs/DB09357/clinical_trials?conditions=DBCOND0050996&phase=3&purpose=treatment&status=completed
37. Study Details | NCT06210373 | Assessment of Efficacy and Safety of the Use of Two Eye Gel Products Containing 5% Dexpanthenol in Patients With Moderate to Severe Dry Eye Syndrome | ClinicalTrials.gov, accessed September 13, 2025, https://www.clinicaltrials.gov/study/NCT06210373
38. Study Results | NCT07002632 | Using Dexpanthenol Cream to Prevent Lip Corner Cracks in Children After Tonsil/Adenoid Surgery | ClinicalTrials.gov, accessed September 13, 2025, https://clinicaltrials.gov/study/NCT07002632?aggFilters=results:with&viewType=Table&rank=1&tab=results
39. A Study to Gain Information How Well Dexpanthenol Dermal Spray Helps the Skin to Recover After a Peeling in the External Genital Area of Women | ClinicalTrials.gov, accessed September 13, 2025, https://www.clinicaltrials.gov/study/NCT03853512
40. A Study to Gain Information How Well Dexpanthenol Dermal Spray Helps the Skin to Recover After a Peeling in the External Genital Area of Women | ClinicalTrials.gov, accessed September 13, 2025, https://clinicaltrials.gov/study/NCT03853512?rank=1
41. NCT03853525 | A Study to Gain Information How Well Dexpanthenol Dermal Spray Helps the Skin to Recover After Laser Hair Removal in the Groin and Intimate Area | ClinicalTrials.gov, accessed September 13, 2025, https://www.clinicaltrials.gov/study/NCT03853525
42. Systemic dexpanthenol as a novel treatment for female pattern hair loss - PubMed, accessed September 13, 2025, https://pubmed.ncbi.nlm.nih.gov/32960484/
43. A new dexpanthenol-containing liquid cleanser for atopic-prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function - PubMed, accessed September 13, 2025, https://pubmed.ncbi.nlm.nih.gov/35866315/
44. Efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms - PMC, accessed September 13, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC10772476/
45. A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function - PMC, accessed September 13, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC9796422/
46. What are the side effects of Dexpanthenol? - Patsnap Synapse, accessed September 13, 2025, https://synapse.patsnap.com/article/what-are-the-side-effects-of-dexpanthenol
47. Allergic contact dermatitis caused by dexpanthenol-Probably a frequent allergen - PubMed, accessed September 13, 2025, https://pubmed.ncbi.nlm.nih.gov/30009460/
48. Allergic contact dermatitis caused by dexpanthenol confirmed with open application test: A case report - ResearchGate, accessed September 13, 2025, https://www.researchgate.net/publication/361837107_Allergic_contact_dermatitis_caused_by_dexpanthenol_confirmed_with_open_application_test_A_case_report
49. Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics, accessed September 13, 2025, https://www.cir-safety.org/sites/default/files/panthenol.pdf
50. Panthoderm, (dexpanthenol) dosing, indications, interactions, adverse effects, and more, accessed September 13, 2025, https://reference.medscape.com/drug/panthoderm-dexpanthenol-999355
51. Dexpanthenol-5-g-100-mg-cream-DEXIPAN-Gulf-Pharmaceutical-Industries-SmPC.pdf - EFDA, accessed September 13, 2025, http://www.efda.gov.et/wp-content/uploads/2023/12/Dexpanthenol-5-g-100-mg-cream-DEXIPAN-Gulf-Pharmaceutical-Industries-SmPC.pdf
52. www.glowm.com, accessed September 13, 2025, https://www.glowm.com/resources/glowm/cd/pages/drugs/d021.html#:~:text=Contraindicated%20in%20patients%20with%20ileus,of%20risk%20of%20severe%20bleeding.&text=Drug%2Ddrug.,to%20dexpanthenol%20(very%20rare).
53. Dexpanthenol: Side Effects, Uses, Dosage, Interactions, Warnings - RxList, accessed September 13, 2025, https://www.rxlist.com/dexpanthenol/generic-drug.htm
54. www.rxlist.com, accessed September 13, 2025, https://www.rxlist.com/dexpanthenol/generic-drug.htm#:~:text=Dexpanthenol%20has%20no%20listed%20serious,moderate%20interactions%20with%20other%20drugs.
55. Is panthenol safe during pregnancy? - Typology, accessed September 13, 2025, https://us.typology.com/library/is-panthenol-safe-during-pregnancy
56. Pantothenic Acid (Vitamin B5) - Uses, Side Effects, and More - WebMD, accessed September 13, 2025, https://www.webmd.com/vitamins/ai/ingredientmono-853/pantothenic-acid-vitamin-b5
57. Bepanthen Ointment 5% Dexpanthenol Skin Irritations tube 30 gr - Mon Pharmacien Conseil, accessed September 13, 2025, https://www.mon-pharmacien-conseil.com/en/drugs/18563-bepanthen-ointment-5-dexpanthenol-skin-irritations-tube-30-gr.html
58. Bepanthen - Bayer, accessed September 13, 2025, https://www.bayer.com/sites/default/files/Bepanthen%20Ointment%20Professional%20Information.pdf
59. Dexpanthenol (Vitamin B5) Injection, 250mg/mL - Olympia Pharmaceuticals, accessed September 13, 2025, https://www.olympiapharmacy.com/product/dexpanthenol/
60. Vitamin B Complex 100 Injection (with Dexpanthenol), Multiple Dose Vial 30 mL | McGuff, accessed September 13, 2025, https://www.mcguff.com/vitamin-b-complex-100-injection-with-dexpanthenol-multiple-dose-vial-30-ml
61. dosage and administration - DailyMed, accessed September 13, 2025, https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=282ccec8-9bcd-4571-9b91-bbb96ef2620d
62. Column A—What information is requested? What is the name of the nominated ingredient? - Regulations.gov, accessed September 13, 2025, https://downloads.regulations.gov/FDA-2013-N-1525-0225/attachment_7.pdf
63. Dexpanthenol: Eczema Uses, Warnings, Side Effects, Dosage - MedicineNet, accessed September 13, 2025, https://www.medicinenet.com/dexpanthenol/article.htm
64. Vitamin B5 (pantothenic acid) dosing, indications, interactions, adverse effects, and more, accessed September 13, 2025, https://reference.medscape.com/drug/vitamin-b5-pantothenic-acid-344423
65. Panthenol Tablets, 100 mg - muller-pharma.com, accessed September 13, 2025, https://www.muller-pharma.com/eshop/panthenol/panthenol-tablety-100-mg-228-p.html
66. Label: BABYSONS- dexpanthenol ointment - DailyMed, accessed September 13, 2025, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a4782fc-5917-4f63-b9bf-6597be2afc6c
67. Pantothenic Acid Uses, Benefits & Dosage - Drugs.com, accessed September 13, 2025, https://www.drugs.com/npp/pantothenic-acid.html
68. Dexpanthenol - brand name list from Drugs.com, accessed September 13, 2025, https://www.drugs.com/ingredient/dexpanthenol.html
69. About Bepanthen globally, accessed September 13, 2025, https://www.bepanthen.co.uk/bepanthen-range/about-bepanthen-globally
70. Dexpanthenol - PharmaKB, accessed September 13, 2025, https://app.pharmakb.com/drugs/Dexpanthenol
71. www.rxlist.com, accessed September 13, 2025, https://www.rxlist.com/dexpanthenol/generic-drug.htm#:~:text=Dexpanthenol%20is%20an%20over%2Dthe,following%20different%20brand%20names%3A%20Panthoderm.
72. dexpanthenol 2 % topical cream - Kaiser Permanente, accessed September 13, 2025, https://healthy.kaiserpermanente.org/health-wellness/drug-encyclopedia/drug.dexpanthenol-2-topical-cream.157722
73. PSUSA/00000999/202401 - periodic safety update report single assessment, accessed September 13, 2025, https://www.ema.europa.eu/en/medicines/psusa/psusa-00000999-202401
74. PUBLIC ASSESSMENT REPORT of the Medicines Evaluation Board in the Netherlands Xylometazoline HCl/Dexpanthenol 0.5/50 mg/ml and 1, accessed September 13, 2025, https://www.cbg-meb.nl/binaries/college-ter-beoordeling-van-geneesmiddelen/documenten/rapporten/2013/06/26/par-xylometazolinehcl-dexpanthenol/130626-par-xylometazolinedexpanthenol-ratiopharm.pdf
75. Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells - PubMed, accessed September 13, 2025, https://pubmed.ncbi.nlm.nih.gov/34698060/
76. (PDF) Effect of dexpanthenol on colonic anastomosis healing in rats - ResearchGate, accessed September 13, 2025, https://www.researchgate.net/publication/329760626_Effect_of_dexpanthenol_on_colonic_anastomosis_healing_in_rats