Sensible Biotechnologies announced a breakthrough in mRNA therapeutic development, achieving a more than 90% reduction in optimization time through an AI-powered platform built on NVIDIA accelerated computing technology. The Boston-based biotechnology company has cut its mRNA optimization cycles from 15 days to just one day, dramatically accelerating the development of next-generation mRNA medicines.
Revolutionary Cell-Based mRNA Platform
Sensible has developed a unique design, optimization, and manufacturing process for producing mRNA drugs within living cells. This cell-based platform creates a pure and low-immunogenicity drug product, unlocking new therapeutic areas with safe, effective, affordable and repeatable mRNA therapeutics. The approach replaces traditional in vitro transcription methods, which are unable to meet the demands of next-generation therapies for cancer, rare diseases, gene editing, and other unmet medical needs.
AI-Driven Molecular Design Technology
The company's proprietary closed-loop AI-powered design and optimization platform models RNA folding from raw sequence to stable conformation. The system integrates NVIDIA technology, including NVIDIA BioNeMo framework and NVIDIA NIM microservices on the NVIDIA DGX Cloud platform with NVIDIA Hopper GPUs, to apply physics-based simulations and machine learning to understand how RNA folds and behaves in complex biological environments.
Using DGX Cloud with NVIDIA H100 80 GB and double-precision performance, Sensible achieves over 11,000 simulation steps per second. This performance enables the team to screen multiple RNA candidates in parallel, reducing simulation runtimes from overnight to under an hour per sequence.
Accelerating Drug Development
The dramatic efficiency improvement enables faster iteration and informed sequence optimization, giving Sensible the ability to rapidly manipulate mRNA design space and advance the next generation of life-saving medicines. "Producing therapeutic mRNA inside living cells requires solving intricate biological problems, from RNA folding to packaging," said Krishna Motheramgari, PhD, Principal Computational Scientist at Sensible Biotechnologies. "With advanced NVIDIA accelerated computing and AI, we can simulate these dynamics rapidly and accurately, accelerating our design cycle dramatically."
Vision for Programmable RNA Medicines
"This technology integration brings us closer to our vision of rationally designed mRNA therapeutics," said Miroslav Gasparek, Chief Executive Officer and co-founder of Sensible Biotechnologies. "By combining our cell-based platform with NVIDIA accelerated computing and AI, we're laying the foundation for programmable, high-performance RNA medicines."
Sensible Biotechnologies is developing the first cell-based platform for the design, optimization, and manufacturing of highly functional, low-immunogenic mRNA, unlocking the therapeutic potential of mRNA for pharma and biotech partners across a wide range of applications. Based in Boston, Oxford and Bratislava, the company has raised more than $13M from leading life science and deep tech investors, including Recode Ventures, BlueYard Capital, Kaya VC, Backed VC, Y Combinator, ZAKA VC, and Onsight.
