Introduction
Aphasia, a communication disorder primarily caused by left-hemisphere stroke, significantly impacts reading abilities in up to 70% of affected individuals, severely affecting their independence and quality of life. Traditional treatments have largely focused on spoken language production, with limited attention to reading impairments. This study introduces a novel approach by combining aerobic exercise training (AET) with phono-motor treatment (PMT) to target reading recovery in aphasia patients.
Study Design
This randomized controlled trial (RCT) compares the effects of AET plus PMT against a control condition of stretching plus PMT. The study aims to assess the impact on reading competence and other language outcomes, including naming, auditory comprehension, and spontaneous speech. Additionally, it investigates the immediate and sustained effects of the intervention on cerebral blood flow (CBF), functional connectivity, and task-evoked brain activity.
Methodology
Participants, recruited from rehabilitation facilities and community organizations, will undergo a series of assessments to evaluate their reading and language abilities before and after the intervention. The study employs a rigorous design, including MRI scans to measure changes in brain activity and connectivity, ensuring a comprehensive understanding of the intervention's impact.
Expected Outcomes
The central hypothesis posits that AET will increase CBF, enhancing the brain's capacity for neuroplasticity when combined with PMT. This synergy is expected to lead to significant improvements in reading recovery and other language functions. The study also aims to provide valuable insights into the neural mechanisms underlying these improvements, potentially paving the way for more effective aphasia treatments.
Conclusion
This Phase I/II RCT represents a significant step forward in the treatment of post-stroke reading impairments. By combining physical and cognitive therapies, the study offers a promising avenue for enhancing language recovery in aphasia patients. The findings could have far-reaching implications for rehabilitation strategies, emphasizing the importance of integrating aerobic exercise with targeted language therapies to improve outcomes for individuals with aphasia.
