PranaX Corporation, an emerging biotechnology company focused on regenerative medicine, announced today that it has secured a licensing agreement with The University of Texas MD Anderson Cancer Center for exosome technology. The technology will be used to develop exosomes as commercial and clinical products aimed at addressing quality of life decline associated with aging, inflammation, and tissue damage.
The comprehensive license grants PranaX access to a core patent portfolio covering exosome manufacturing, engineering, and therapeutic applications. This agreement enables the company to commercialize exosomes as therapeutics, physician-directed supplements, and wellness products designed to promote healthy aging and combat chronic disease.
"We are thrilled to have secured a license for these technologies, empowering us to develop and advance our commercial exosome product line," said Phillip Maderia, CEO of PranaX Corporation. "This technology holds the promise of revolutionizing the treatment of age-related conditions in humans."
Technology with Clinical Validation
The licensed technology was previously used in the first FDA-approved trial to test mesenchymal stem cell derived exosomes in cancer patients. PranaX plans to combine its in-house regenerative medicine technology with MD Anderson's clinical exosomes knowledge base to advance evidence-based applications in regenerative medicine.
Steven J. Greco, PhD, Founder and Chief Operating Officer of PranaX, emphasized the significance of the acquisition: "This is an amazing opportunity to harness best-in-class technology that has been tested in the clinic through Phase I safety studies. PranaX intends to expand these data to enhance quality of life during the later stages of adulthood."
Under the agreement terms, MD Anderson will license stem cell exosome manufacturing technology that was used in its Phase I study targeting KRASG12D in pancreatic cancer. This technology will serve as the foundation for PranaX's ExoWELL™ platform. The licensing agreement also allows PranaX to develop several clinical programs for non-cancer indications, specifically focusing on age-related chronic diseases.
ExoWELL™: First Commercial Product
The company's first commercial product, ExoWELL™, is a physician-directed, GMP stem cell exosome supplement designed for health and wellness applications. According to PranaX, the product has potential to modulate cellular function and promote tissue regeneration.
Exosomes are extracellular vesicles that play crucial roles in intercellular communication by transferring proteins, lipids, and genetic material between cells. Their ability to influence cellular behavior makes them promising candidates for therapeutic applications in regenerative medicine.
Manufacturing and Banking Capabilities
PranaX has established its headquarters in Houston, featuring a GMP-compliant facility designed to streamline the transfer of MD Anderson's exosome manufacturing technology. This facility will enable the production of both commercial and clinical stem cell exosome products.
In addition to product development, PranaX will utilize the facility to offer exosome banking services under its ExoSTORE™ brand. This service will provide personalized collection and banking of exosomes from multiple sources, including peripheral blood, umbilical cord blood, and neonatal tissues.
The company's approach represents a growing trend in regenerative medicine that focuses on harnessing cellular components rather than whole cells themselves. By focusing on exosomes, PranaX aims to develop products that can address the biological mechanisms underlying aging and chronic disease through targeted cellular modulation.
As the field of exosome-based therapeutics continues to evolve, PranaX's licensing agreement positions the company to potentially play a significant role in bringing these advanced technologies from clinical research into commercial applications that could benefit patients dealing with age-related conditions.
