Persistent Lyme Empiric Antibiotic Study Europe (PLEASE) - design of a ...
The PLEASE study is a double-blind, randomized trial comparing long-term antibiotic treatments (doxycycline or clarithromycin with hydroxychloroquine) to placebo in patients with borreliosis-attributed persistent symptoms. It aims to assess the efficacy of prolonged antibiotic therapy on health-related quality of life, fatigue, neuropsychological outcomes, and cost-effectiveness.
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The PLEASE study is a double-blind, randomized trial comparing long-term antibiotic treatments (doxycycline or clarithromycin with hydroxychloroquine) to placebo in patients with borreliosis-attributed persistent symptoms. It aims to assess the efficacy of prolonged antibiotic therapy on health-related quality of life, fatigue, neuropsychological outcomes, and cost-effectiveness.