Ozempic, Wegovy Won't Raise User's Suicide Risk, Study Finds
A study finds that semaglutide, used in weight-loss drugs Ozempic and Wegovy, does not increase suicide risk or depression in users without known mental health disorders. The analysis of over 3,500 participants in clinical trials showed no significant difference in suicidal thoughts or behaviors between those taking semaglutide and a placebo, with fewer depressive symptoms reported in the semaglutide group.
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A study finds that semaglutide, used in weight-loss drugs Ozempic and Wegovy, does not increase suicide risk or depression in users without known mental health disorders. The analysis of over 3,500 participants in clinical trials showed no significant difference in suicidal thoughts or behaviors between those taking semaglutide and a placebo, with fewer depressive symptoms reported in the semaglutide group.
Semaglutide, sold as Ozempic and Wegovy, shows psychiatric safety in those without significant mental health disorders, according to a JAMA Internal Medicine study. The drug, used for obesity treatment, demonstrated no increased risk of depression or suicidal ideation compared to placebo. However, further research is needed for patients with severe mental health conditions.
A study from Perelman School of Medicine, published in JAMA Internal Medicine, found that semaglutide, a weight loss medication, did not increase the risk of depressive symptoms, suicidal thoughts, or behavior in individuals without major mental health disorders. Led by Thomas Wadden, the study analyzed data from over 3,500 participants in four clinical trials.
Analysis of WHO ADR data shows suicidality and self-harm with semaglutide, but not in clinical trials or a large cohort study. Both studies excluded patients with mental health history, leaving unanswered if GLP-1 receptor agonists worsen symptoms in such patients. Rapid weight loss due to semaglutide may exacerbate mental distress in vulnerable patients, necessitating continued vigilance and further research.