The UK's Medicines and Healthcare products Regulatory Agency (MHRA) is currently investigating 10 reported deaths that may be linked to the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs), commonly used as weight loss injections. This announcement follows a significant number of adverse event reports associated with drugs like Wegovy and Ozempic.
Adverse Event Reports
In addition to the reported deaths, the MHRA has received 7,228 reports of side effects including nausea, vomiting, and diarrhea related to the use of these weight loss medications. Of these cases, 68 individuals required hospitalization, highlighting the severity of some adverse reactions.
The MHRA has clarified that a reported death does not automatically indicate that the medication was the definitive cause. Underlying or concurrent illnesses, other medications, or coincidental events could also be contributing factors. The agency emphasized this point in a statement to Chemist and Druggist magazine.
MHRA Guidance for Healthcare Professionals
Last week, the MHRA issued an alert urging healthcare professionals to remain vigilant for potential misuse of GLP-1RAs and to report any concerns. The guidance specifically highlights the importance of informing patients about both common and serious side effects associated with these medications.
The MHRA alert also addresses the potential misuse of GLP-1RAs for unauthorized indications, such as aesthetic weight loss. The agency advises healthcare professionals to be alert for signs of misuse among their patients, warn them about the risk of side effects, and report any adverse reactions they may experience.
Risks of Counterfeit Medications
The MHRA has also raised concerns about the risks associated with counterfeit GLP-1RA medications being used for weight loss. These falsified medicines have been found to contain insulin, posing a significant risk to users who are unaware of the contents. Patients need to be aware of the risks associated with counterfeit GLP-1RA medications being used for weight loss.
