Hoth Therapeutics, Inc. (NASDAQ: HOTH) has announced positive data from a first-of-its-kind human patient case involving the treatment of epidermal growth factor receptor inhibitor (EGFRI) associated papulopustular eruptions (PPEs) with its novel therapeutic, HT-001. The case demonstrated rapid resolution of symptoms, allowing the patient to discontinue treatment after only one week. This marks a significant advancement in managing a common and debilitating side effect experienced by cancer patients undergoing EGFRI therapy.
Rapid Symptom Resolution with HT-001
The reported case involved a 59-year-old female undergoing treatment at George Washington University for metastatic breast cancer. The patient experienced significant improvement in symptoms just one week after initiating HT-001 therapy. The swift resolution of lesions and alleviation of discomfort allowed the patient to discontinue the treatment after just seven days. Over the following three weeks, no new lesions developed, further highlighting the potential of HT-001 as an effective and safe therapy for EGFRI-associated PPEs.
The Challenge of EGFRI-Induced Skin Toxicities
EGFRIs are widely used to treat various cancers of epithelial origin but are frequently associated with cutaneous side effects, most notably PPEs like acneiform rash, which can occur in up to 90% of patients. These PPEs can cause significant discomfort, including pruritus and burning, and often lead to interruptions or discontinuation of critical cancer therapies. HT-001 offers a new approach to managing these skin toxicities, showing rapid symptom relief without compromising the patient's ongoing cancer treatment.
Management Perspective
"We are thrilled with the positive data from this first investigator led study patient case," said Robb Knie, CEO of Hoth Therapeutics. "HT-001 has the potential to significantly improve the quality of life for cancer patients suffering from EGFRI-induced skin toxicities. This rapid and successful treatment is an important milestone as we continue to explore HT-001's potential to meet this critical unmet need."
Ongoing Clinical Evaluation
A Phase 2a clinical trial is currently underway to further evaluate the efficacy and safety of HT-001 in the management of EGFRI-associated skin toxicities. Current sites include MD Anderson Cancer Center, University of Miami, Dana Farber Cancer Institute, University of California Irvine, the George Washington University, Montefiore Medical Center, and Northwell Health, Inc.
