Low-Dose Triple-Pill vs Standard-Care Protocols for Hypertension Treatment in Nigeria
Low-dose triple-pill protocol significantly reduced home systolic blood pressure by 5.8 mm Hg in a randomized trial in Nigeria among 300 Black African patients with uncontrolled hypertension, compared to standard-care protocol, with no increase in treatment discontinuation due to adverse events. This suggests that the triple-pill protocol can improve blood pressure lowering compared to standard care, potentially addressing the high burden of hypertension in sub-Saharan Africa.
Reference News
Low-dose triple-pill protocol significantly reduced home systolic blood pressure by 5.8 mm Hg in a randomized trial in Nigeria among 300 Black African patients with uncontrolled hypertension, compared to standard-care protocol, with no increase in treatment discontinuation due to adverse events. This suggests that the triple-pill protocol can improve blood pressure lowering compared to standard care, potentially addressing the high burden of hypertension in sub-Saharan Africa.
A study in Nigeria found a low-dose triple-drug combination pill safe and effective for hypertension control in Black Africans, with significant blood pressure reduction at 6 months compared to standard care, highlighting the need for long-term safety data and implementation science to improve hypertension control in sub-Saharan Africa.