Dewpoint Therapeutics announced the closing of its Series D financing round on September 10, 2025, securing funding to advance DPTX3186, a first-in-class condensate modulator (c-mod), into clinical trials by year-end 2025. The Boston-based biotechnology company plans to deliver early clinical proof-of-concept data by the end of 2026 for this novel therapeutic targeting gastric cancer.
Novel Mechanism Targets Wnt Signaling
DPTX3186 represents an orally delivered small molecule with a unique mechanism of action designed to selectively disrupt oncogenic Wnt signaling. The drug forces β-catenin to concentrate in an inactive condensate preferentially within cancer cells. This selective modulation of β-catenin has the potential to address long-standing safety concerns, including bone and gastrointestinal toxicity, that have historically limited Wnt-targeted therapies.
The therapeutic approach leverages condensate biology, where condensates are membraneless organelles that form dynamically throughout cells via phase separation. These subcellular compartments organize and concentrate molecules within cells to enable key biochemical processes. The dysregulation of biomolecular condensates has been observed in many diseases, including cancer, diabetes, cardiopulmonary and neurological disorders.
Expanding Pipeline and Strategic Partnerships
The Series D financing will also accelerate development of Dewpoint's first-in-class c-mod targeting MYC, another historically 'undruggable' target, while strengthening ongoing collaborations with Bayer, Novo Nordisk, and Mitsubishi Tanabe Pharma. The funding provides operational runway into early 2027.
"This financing allows us the opportunity to demonstrate the promise of condensate biology in the clinic, with DPTX3186 laying the foundation for creating an entirely new class of condensate modulating therapeutics with broad potential, a milestone for both science and our investors," said Ameet Nathwani, MD, CEO of Dewpoint Therapeutics.
Platform Technology and Therapeutic Potential
Dewpoint positions itself as the leading biotech company in applying biomolecular condensate biology toward developing therapeutics for diseases of high unmet need. The company's proprietary AI/ML-powered platform underlies a drug discovery pipeline spanning multiple therapeutic areas, including oncology, neurodegenerative, cardiopulmonary, and metabolic diseases.
The realization that a vast range of conditions are regulated by or arise from condensate dysfunction has provided new possibilities for modulating high-value targets previously deemed 'undruggable,' opening unexplored avenues to identify hundreds of novel therapeutic targets. Condensate-modulating drugs potentially provide novel therapeutic options for complex diseases and historically undruggable targets.
The Series D round was supported by a syndicate of existing investors aligned with Dewpoint's strategic vision who continue to support the company's strategy and scientific progress as it enters the clinical development phase.
