Thoracic Oncology Program Research - UCSF
The Jablons' lab has advanced novel pan RAS and dual anti-PARP/anti-microtubule inhibitors in clinical trials, and is conducting an international trial for an early-stage lung cancer diagnostic assay. Ongoing basic research focuses on developmental pathways like WNT and Hippo signaling, with immuno-therapeutic approaches targeting these pathways. A 14 gene molecular assay for early-stage non-small cell lung cancer predicts prognosis and guides adjuvant therapy, saving thousands of patients. The lab also demonstrated aberrant Wnt signaling causing lung cancer and mesothelioma, developing an anti-Wnt2-ADC showing significant anti-tumor effects, with a Phase I trial upcoming.
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The Jablons' lab has advanced novel pan RAS and dual anti-PARP/anti-microtubule inhibitors in clinical trials, and is conducting an international trial for an early-stage lung cancer diagnostic assay. Ongoing basic research focuses on developmental pathways like WNT and Hippo signaling, with immuno-therapeutic approaches targeting these pathways. A 14 gene molecular assay for early-stage non-small cell lung cancer predicts prognosis and guides adjuvant therapy, saving thousands of patients. The lab also demonstrated aberrant Wnt signaling causing lung cancer and mesothelioma, developing an anti-Wnt2-ADC showing significant anti-tumor effects, with a Phase I trial upcoming.