Neutrophil exhaustion and impaired functionality in psoriatic arthritis patients - Frontiers
Study evaluates PMNs and NETs in PsA patients, finding distinct phenotypic and functional deficits compared to HCs, including lower expression of activation markers, reduced ROS production, diminished phagocytosis, and less granular enzyme and NET biomarker release. Elevated serum levels of neutrophil-related mediators and NET biomarkers in PsA patients suggest a distinct neutrophil signature associated with PsA.
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Study evaluates PMNs and NETs in PsA patients, finding distinct phenotypic and functional deficits compared to HCs, including lower expression of activation markers, reduced ROS production, diminished phagocytosis, and less granular enzyme and NET biomarker release. Elevated serum levels of neutrophil-related mediators and NET biomarkers in PsA patients suggest a distinct neutrophil signature associated with PsA.