Lehigh Valley Health Network (LVHN) is participating in a clinical trial evaluating drug-coated balloons (DCB) as a novel treatment for obstructed coronary arteries. This late-stage trial could revolutionize the treatment of coronary artery disease by offering an alternative to traditional stenting procedures.
Potential Benefits of Drug-Coated Balloons
For suitable patients, DCBs may reduce the need for stents, particularly in smaller arteries where stenting is less effective. This approach offers the potential for long-lasting improvements in blood flow. According to Chirdeep Patel, MD, an interventional cardiologist at Lehigh Valley Heart and Vascular Institute, this trial expands the possibilities for treating various types of blockages, offering additional options and potentially better outcomes for patients.
How Drug-Coated Balloons Work
The DCB procedure begins with balloon angioplasty, where a catheter is inserted into a large blood vessel and guided to the blocked artery. A balloon is then advanced through the catheter and inflated to reopen the artery. Unlike traditional angioplasty, the DCB delivers a drug directly to the artery wall during the inflation process. This drug helps prevent the artery from narrowing again, reducing the risk of restenosis without the need for a permanent stent implant.
Current Treatment Landscape
Balloon angioplasty followed by stenting has been the standard treatment for coronary artery disease for over two decades. Stents are metal mesh tubes that remain in the artery to keep it open. While effective, stents can sometimes lead to complications such as blood clots or the need for additional procedures. Drug-coated balloons offer a promising alternative that may mitigate these risks.
Implications for Patients
If the clinical trial is successful and the drug-coated balloons are approved, it could significantly impact the treatment of coronary artery disease. Patients who are not candidates for stenting or those with smaller arteries may benefit from this less invasive approach. The potential reduction in the need for stents could also lead to fewer long-term complications and improved quality of life for patients.
