Abemaciclib Monotherapy Elicits No Response in Advanced RCC - OncLive
A phase 1b study of abemaciclib monotherapy in heavily pretreated patients with metastatic ccRCC showed no clinically meaningful activity, with no objective responses and rapid disease progression in most patients. Despite the negative results, these findings are crucial for understanding the potential of CDK4/6 inhibitors in combination therapies for RCC, guiding future trials.
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A phase 1b study of abemaciclib monotherapy in heavily pretreated patients with metastatic ccRCC showed no clinically meaningful activity, with no objective responses and rapid disease progression in most patients. Despite the negative results, these findings are crucial for understanding the potential of CDK4/6 inhibitors in combination therapies for RCC, guiding future trials.