Merck Announces Phase 3 Trial Initiation for Bomedemstat, an Investigational Candidate for ...
Merck initiates Shorespan-007, a Phase 3 trial evaluating bomedemstat for essential thrombocythemia (ET) patients not previously treated with cytoreductive therapy, aiming to address unmet needs in myeloproliferative neoplasms (MPNs).
Related Clinical Trials
Highlighted Terms
Related News
Merck launched Shorespan-007, a Phase 3 trial evaluating bomedemstat for essential thrombocythemia (ET) patients not on cytoreductive therapy. Bomedemstat is compared to hydroxyurea in 300 ET patients, with primary and secondary endpoints focusing on response rates and symptom scores. Bomedemstat also has FDA Orphan Drug and Fast Track designations for ET and myelofibrosis, and a Priority Medicines designation for myelofibrosis by the EMA.
Merck initiates Shorespan-007, a Phase 3 trial evaluating bomedemstat for essential thrombocythemia (ET) patients not previously treated with cytoreductive therapy, aiming to address unmet needs in myeloproliferative neoplasms (MPNs).
Merck initiates Phase 3 trial, Shorespan-007, evaluating bomedemstat, an LSD1 inhibitor, for treating essential thrombocythemia (ET) patients not previously treated with cytoreductive therapy. The trial aims to compare bomedemstat with standard care chemotherapy, hydroxyurea, with a focus on durable clinicohematologic response rate and patient-reported outcomes. Bomedemstat holds FDA Orphan Drug and Fast Track Designations for ET and myelofibrosis.
A phase 3 trial (NCT06456346) has begun to assess bomedemstat (MK-3543; IMG-7289) for essential thrombocythemia (ET) patients not previously treated with cytoreductive therapy. The Shorespan-007 trial will compare bomedemstat with standard-of-care hydroxyurea in treatment-naive ET patients, with primary end points including durable clinicohematologic response rate and secondary end points like duration of hematologic remission and event-free survival. Bomedemstat has received FDA orphan drug and fast track designations for ET and myelofibrosis.
A phase 3 clinical trial for essential thrombocythemia patients has launched, investigating bomedemstat as a potential new treatment. The trial, named Shorespan-007, aims to compare bomedemstat to standard chemotherapy, hydroxyurea, and is expected to conclude in May 2029.
Merck's Phase III Shorespan-007 trial evaluates bomedemstat for essential thrombocythemia (ET) in patients not previously treated with cytoreductive therapy, comparing it to hydroxyurea. The trial aims to improve disease control and quality of life for ET patients, with endpoints including durable clinicohematologic response rate and patient-reported outcomes. Bomedemstat has received Orphan Drug and Fast Track designations for ET and myelofibrosis.