A team at the West Pomeranian University of Technology (ZUT) and the Pomeranian Medical University (PUM) has developed an innovative approach to treating ovarian cancer using nanotechnology. The method aims to deliver drugs directly to cancer cells while sparing healthy tissue, addressing a significant challenge in ovarian cancer treatment where tumor cells often spread within the abdominal cavity.
Targeting Mucins with Nanoparticles
The novel treatment targets mucins, proteins produced by ovarian cancer cells that form a protective shield. Dr. Agnieszka Piegat, who leads the research, explained that the nanoparticles are designed to identify and target these mucins, delivering the drug specifically to the cancer cells while leaving healthy cells unaffected. This targeted approach contrasts with conventional cancer treatments like chemotherapy, which can damage healthy cells and cause severe side effects.
Promising Preclinical Results
Preclinical trials on animals have shown promising results. According to Dr. Piegat, the researchers have observed a halt in tumor growth and improved overall condition in animals treated with this therapy compared to traditional drug delivery methods. Researchers are currently analyzing the distribution of the medication within the body and its effects on internal organs and gut flora.
From Stomach Ulcers to Ovarian Cancer
The project, supervised by Prof. Aneta Cymbaluk-Płoska and Prof. Danuta Bogacka, evolved from the Polish "Lider" program, which initially focused on developing drug delivery carriers for treating stomach ulcers caused by Helicobacter pylori. Encouraged by the success of that research, the team adapted the technology for ovarian cancer, encapsulating carboplatin, a commonly used chemotherapy drug, within the nanoparticles.
Future Directions
While the treatment is still in the preclinical phase, its success in animal trials represents a significant advancement. Further studies are underway to refine the method and assess its long-term impact. If successful, this approach could revolutionize cancer treatment, providing more effective and less invasive options for patients.
