Axsome Therapeutics has announced positive results from its ACCORD-2 phase III trial of AXS-05 (dextromethorphan-bupropion) in patients with agitation related to Alzheimer's disease. The trial met its primary endpoint, offering a potential new treatment option for this common and distressing symptom.
Semaglutide as a Potential Alzheimer's Therapy
Two clinical trials are underway to evaluate semaglutide (Ozempic, Wegovy) as a possible early intervention for Alzheimer's disease. Results from these trials are expected in 2025, and could offer a novel approach to disease modification.
Gut Microbiome and Alzheimer's Disease
Emerging research suggests a link between the gut microbiome and Alzheimer's disease. A recent study found that Alzheimer's disease-associated CD83(+) microglia were associated with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain, highlighting a potential role for the gut-brain axis in the pathogenesis of Alzheimer's.
Other Alzheimer's Updates
A phase IIa trial investigating nicotinamide in individuals with mild cognitive impairment or mild dementia found the treatment to be safe but ineffective in altering Alzheimer's biomarkers.
