Adoption of Total Neoadjuvant Therapy in the Treatment ...
TNT, adopted as standard care for LARC, shows improved outcomes over traditional treatments, including longer DFS and MFS, higher pCR rates, and reduced distant metastases. Studies like UNICANCER-PRODIGE 23 and RAPIDO highlight TNT's benefits, though questions remain on the impact of adjuvant chemotherapy. TNT's effectiveness varies, with some studies showing no significant differences in outcomes.
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TNT, adopted as standard care for LARC, shows improved outcomes over traditional treatments, including longer DFS and MFS, higher pCR rates, and reduced distant metastases. Studies like UNICANCER-PRODIGE 23 and RAPIDO highlight TNT's benefits, though questions remain on the impact of adjuvant chemotherapy. TNT's effectiveness varies, with some studies showing no significant differences in outcomes.