Cytokine Profile at Diagnosis Affecting Trough ...
This study investigates cytokine concentrations in Crohn's disease (CD) patients to assess their impact on infliximab (IFX) treatment response. Findings indicate high initial TNF-α levels correlate with lower IFX trough concentrations, suggesting a need for adjusted dosing. The study highlights the complex interplay of cytokines in CD and their potential role in predicting treatment outcomes.
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Study on pediatric Crohn's disease shows higher cytokine levels (TNF-α, IL-6, IL-10, IL-17A) in non-remission patients. Initial TNF-α levels negatively correlate with infliximab (IFX) trough concentration. TNF-α >27.6 pg/mL suggests higher IFX doses may be needed for therapeutic efficacy.
This study investigates cytokine concentrations in Crohn's disease (CD) patients to assess their impact on infliximab (IFX) treatment response. Findings indicate high initial TNF-α levels correlate with lower IFX trough concentrations, suggesting a need for adjusted dosing. The study highlights the complex interplay of cytokines in CD and their potential role in predicting treatment outcomes.