enGene Holdings Inc. (NASDAQ:ENGN) has announced the appointment of Raj Pruthi MD MHA FACS as Senior Vice President, Urologic Oncology and Clinical Development. Dr. Pruthi will report to enGene's Chief Medical Officer, Dr. Richard Bryce, and will be responsible for supporting the clinical development of EG-70 across the urologic space, including engagement with the urological community.
EG-70: A Novel Approach to NMIBC
EG-70, enGene's lead product candidate, is a non-viral, intravesical genetic medicine currently in a pivotal study for BCG-unresponsive non-muscle invasive bladder cancer (NMIBC). NMIBC represents a significant clinical challenge, with a substantial proportion of patients failing to respond to Bacillus Calmette-Guérin (BCG) therapy, the current standard of care. This creates an urgent need for new and effective treatment options.
Dr. Pruthi's Role and Expertise
Dr. Pruthi's extensive experience in urologic oncology will be instrumental in guiding the clinical development of EG-70. His responsibilities include fostering relationships with key opinion leaders and urological experts to enhance understanding and adoption of EG-70, if approved. enGene aims to leverage Dr. Pruthi's expertise to optimize the clinical trial design and execution, potentially accelerating the path to regulatory approval and patient access.
Addressing Unmet Needs in Bladder Cancer
The development of EG-70 represents a promising advancement in the treatment landscape for NMIBC. By offering a novel, non-viral approach, EG-70 has the potential to overcome the limitations of existing therapies and improve outcomes for patients with BCG-unresponsive disease. The ongoing pivotal study is designed to evaluate the efficacy and safety of EG-70 in this patient population, with the goal of providing a much-needed alternative treatment option.
