Halia Therapeutics, a clinical-stage biopharmaceutical company, announced that its President and CEO, David J. Bearss, Ph.D., will participate in a panel discussion at the BIO Investor Forum in San Francisco on October 15, 2024. The panel, titled 'Expansion of Neurodegenerative Disease Targets and Pipelines,' will explore the latest advancements in diverse approaches to neurodegenerative diseases, novel targets, and the implications for future treatment and investment opportunities.
HT-4253: Targeting Neuroinflammation in Neurodegenerative Diseases
Halia Therapeutics is currently evaluating HT-4253, an orally administered small molecule, in a Phase 1 clinical trial (NCT06537817). This trial aims to assess the safety, tolerability, and pharmacokinetics of HT-4253 in healthy adult volunteers. HT-4253 functions by inhibiting leucine-rich repeat kinase 2 (LRRK2), a key regulator of neuroinflammation implicated in the pathogenesis of Alzheimer's and Parkinson's disease.
Chronic inflammation in the brain is recognized as a significant driver of neurodegenerative diseases. Halia's scientists have demonstrated that LRRK2 plays an essential role in regulating neuroinflammation. By inhibiting LRRK2 with HT-4253, Halia Therapeutics aims to modify the progression of neurodegenerative diseases by addressing their inflammatory component.
Halia Therapeutics' Broader Pipeline
Halia Therapeutics is also developing HT-6184, a NEK7/NLRP3 inhibitor, which has completed a Phase 1 study (NCT05447546). Furthermore, two Phase 2 trials have been initiated to evaluate the efficacy of HT-6184 in treating lower-risk myelodysplastic syndromes (LR-MDS) and its impact on post-procedure diagnostic biomarkers of inflammation and pain (NCT06241742).
BIO Investor Forum Participation
Dr. Bearss will be available for one-on-one investor meetings with registered conference attendees at the BIO Investor Forum, providing an opportunity to discuss Halia Therapeutics' innovative approach to treating inflammatory and neurodegenerative diseases. The BIO Investor Forum focuses on showcasing drug development programs ready for partnering and venture funding, with the ultimate goal of accelerating the progress of new therapeutic technologies into commercialization to benefit patients.
