KNDY Neuron Research Leads to New Drugs for Infertility, Menopause Symptoms
Key Insights
Researchers have developed drugs targeting KNDY neurons to treat reproductive system malfunctions, including infertility (search) and menstrual issues.
One drug, developed following the discovery of KNDY neurons, has already received FDA approval for treating hot flashes by blocking neurokinin B (search) (NKB).
Clinical trials are underway for additional drugs to address conditions like delayed puberty and PCOS (search), potentially revolutionizing treatment within five years.
Drugs targeting reproductive system malfunctions such as infertility (search), menstrual issues, delayed onset of puberty, and hot flashes—a common symptom of menopause (search)—are under development following groundbreaking research on KNDY (kisspeptin, neurokinin B (search), and dynorphin A) neurons. Clinical studies are underway, and some drugs have already received approval, according to Michael Lehman, Director of the Brain Health Research Institute, Kent State University, Ohio.
Discovery of KNDY Neurons
Lehman, along with Lique Coolen and Robert Goodman, discovered KNDY neurons approximately 15 years ago. These neurons are a critical part of the brain controlling puberty, the menstrual cycle, and reproduction in adults. "The study resulted in the discovery of KNDY neurons around 15 years ago. The neurons are a critical part of the brain controlling puberty, the menstrual cycle, and reproduction in adults," Lehman stated.
Novel Treatments for Reproductive Disorders
The discovery of KNDY neurons has facilitated the development of drugs to treat a variety of disorders, including infertility (search), hot flashes, and PCOS (search). A drug blocking NKB, a component of KNDY neurons, has been approved by the USFDA for preventing hot flashes. "Hot flashes episodes are very disruptive... The drug, developed after our discovery, blocks NKB, preventing hot flashes. The drug has been approved by USFDA," Lehman explained.
From Animal Models to Clinical Translation
The basic science study, based on animal models, particularly sheep, has led to clinical translation. This has provided doctors with a new drug to use in treating hot flashes. Lehman emphasized that this is an example of how understanding the brain helps in finding new ways of treating disease.
Supporting Future Research
Lehman, also the Editor-in-Chief of the Journal of Neuroendocrinology, highlighted the journal's commitment to supporting the training of the next generation of researchers. The journal publishes research on understanding how the brain controls hormones and their influence on the brain in health and disease. It supports researchers' and students' careers by providing financial support for the skilling of delegates and conferences worldwide.