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A Potent Zwitterionic Inhibitor of KHK

Resmetirom (REZDIFFRA™) became the first FDA-approved treatment for NASH on Mar. 14th, 2024. This oral, liver-targeting THR-β-selective agonist, discovered at Roche Nutley, was highlighted as Molecule of the Month in Dec. 2022 and is a 2023 Molecule of the Year nominee.


Reference News

A Potent Zwitterionic Inhibitor of KHK

Resmetirom (REZDIFFRA™) became the first FDA-approved treatment for NASH on Mar. 14th, 2024. This oral, liver-targeting THR-β-selective agonist, discovered at Roche Nutley, was highlighted as Molecule of the Month in Dec. 2022 and is a 2023 Molecule of the Year nominee.

An Oral, Small Molecule GLP-1R Agonist Fast-Follower from Structure Therapeutics

Resmetirom (REZDIFFRA™) became the first FDA-approved treatment for NASH on Mar. 14th, 2024. This oral, liver-targeting THR-β-selective agonist, originally discovered at Roche Nutley, was first highlighted in Dec. 2022 and is now a 2023 Molecule of the Year nominee.

A First-in-Class, Selective PPARδ Agonist from Gilead Approved for Primary Biliary Cholangitis

Resmetirom (REZDIFFRA™) became the first FDA-approved treatment for NASH on Mar. 14th, 2024, marking a historic milestone in liver drug discovery.

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