ITM Isotope Technologies Munich SE announced it will present additional analysis from its recently completed Phase 3 COMPETE trial at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) annual meeting, scheduled for June 21-24, 2025 in New Orleans, Louisiana. The presentations will provide deeper insights into the company's successful radiopharmaceutical therapy for gastroenteropancreatic neuroendocrine tumors.
Key Presentations at SNMMI 2025
Dr. Thomas A. Hope, Chief of Nuclear Medicine at the San Francisco VA Medical Center and Vice Chair of Clinical Operations and Strategy in the Department of Radiology at UCSF, will deliver an oral presentation titled "Predicting the [177Lu]Lu-edotreotide uptake in tumors using pre-therapeutic Ga-68 PET/CT imaging" on Sunday, June 22 from 3:30-4:45 pm CDT. The presentation will analyze 177Lu-edotreotide tumor uptake and its predictability based on pre-therapeutic SSTR PET/CT imaging and other factors.
A satellite symposium, "Pursuing the Art and Science of RPT: COMPETE Results and the Evolution of Dosimetry," will take place on Sunday, June 22 from 6:30-7:30 pm CDT at the Ernest N. Morial Convention Center. The symposium will feature an overview of the GEP-NET treatment landscape, including findings from the Phase 3 COMPETE trial, and perspectives on dosimetry standardization.
COMPETE Trial Results
The COMPETE trial evaluated 177Lu-edotreotide (ITM-11), a proprietary, synthetic, targeted radiotherapeutic agent compared to everolimus, a targeted molecular therapy, in patients with inoperable, progressive Grade 1 or Grade 2 gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The trial met its primary endpoint, with 177Lu-edotreotide demonstrating clinically and statistically significant improvement in progression-free survival compared to everolimus. ITM announced the positive Phase 3 results in March 2025.
Expert Speakers and Topics
The symposium will feature presentations from leading experts in the field. Dr. Jonathan Strosberg, Section Head of the Neuroendocrine Division and Program Chair of the Gastrointestinal Department Oncology Research Program at Moffitt Cancer Center, will discuss the GEP-NET treatment landscape, COMPETE trial results, and COMPOSE trial design. Dr. John Sunderland, Professor of Radiology in the Nuclear Medicine Division at the University of Iowa, will present on the COMPETE dosimetry sub-study and the evolution of dosimetry.
Expanding Clinical Development
177Lu-edotreotide is also being evaluated in COMPOSE, a Phase 3 study in patients with well-differentiated, aggressive Grade 2 or Grade 3, SSTR-positive GEP-NET tumors, demonstrating ITM's commitment to expanding treatment options for neuroendocrine tumor patients.
Company Leadership Participation
Dr. Celine Wilke, ITM's Chief Medical Officer, will participate in the "Entrepreneur's Panel: Community Based Sites – Accelerating Clinical Trials and Expanding Access" on Saturday, June 21 from 3:30-4:45 pm CDT. ITM will maintain a presence at booth 1001, providing information on the company's latest innovations in radiopharmaceutical therapy, its pipeline of RPT therapeutics, and capabilities to produce high-quality medical radioisotopes for global partners.
ITM describes itself as a leading radiopharmaceutical biotech company dedicated to providing a new generation of radiopharmaceutical therapeutics and diagnostics for hard-to-treat tumors. The company advances a broad precision oncology pipeline, including multiple Phase 3 studies, combining high-quality radioisotopes with a range of targeting molecules.
