Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic ...
A phase I trial (BrainChild-03) tested B7-H3-specific CAR T cells in children with DIPG, showing feasibility of repeated intracranial dosing, local immune activation, and CAR T cells persistence in CSF, with one patient showing sustained improvement over 12 months.
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Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic ...
A phase I trial (BrainChild-03) tested B7-H3-specific CAR T cells in children with DIPG, showing feasibility of repeated intracranial dosing, local immune activation, and CAR T cells persistence in CSF, with one patient showing sustained improvement over 12 months.