High Q Technologies and Creative Biostructure Form Strategic Partnership to Advance Quantum EPR Spectroscopy in Drug Discovery
Key Insights
High Q Technologies (search) and Creative Biostructure (search) announced a strategic partnership to support broader adoption of EPR spectroscopy for studying protein (search) dynamics in pharmaceutical and biotechnology research.
The collaboration combines High Q's FATHOM® quantum EPR spectroscopy platform with Creative Biostructure (search)'s expertise in experimental design and workflow support to make advanced protein (search) analysis more accessible.
EPR spectroscopy addresses limitations of static structural methods by enabling researchers to study disordered, flexible protein (search) systems and molecular motion implicated in challenging health conditions.
High Q Technologies (search), a developer of quantum-enabled electron paramagnetic resonance (EPR) spectroscopy systems, and Creative Biostructure (search), a structural biology Contract Research Organization, have announced a strategic partnership to support broader adoption of EPR spectroscopy for studying protein (search) dynamics in pharmaceutical and biotechnology research.
Addressing Drug Discovery Challenges
EPR spectroscopy is increasingly relevant as drug discovery turns toward disordered, flexible, and disease-relevant protein (search) systems that cannot be fully understood through static structural methods alone. However, broad adoption of EPR has historically been limited by instrument and workflow complexity, and the need for dedicated technical expertise in experimental design and data interpretation.
Leveraging quantum sensor technology, High Q's FATHOM® EPR (search) platform has overcome these challenges by providing unique measurements of long-range distances. This enables researchers to probe conformational ensembles and molecular motion implicated in today's most challenging health conditions where intrinsic disorder, aggregation, and dynamic intermediates drive pathology.
Partnership Details
Through the collaboration, Creative Biostructure (search) will provide scientific consultation, experimental design support, and workflow guidance for organizations implementing High Q Technologies (search)' FATHOM® EPR (search) spectroscopy platform.
"Drug discovery is increasingly focused on understanding how proteins behave in motion," said Don Carkner, Managing Director at High Q Technologies (search). "With FATHOM®, quantum-enabled EPR spectroscopy provides a way to study these dynamic systems, and through this partnership with Creative Biostructure (search), we are making these capabilities more accessible within structural biology and drug discovery workflows."
Integrative Structural Biology Approach
Tony Zhang, Principal Scientist at Creative Biostructure (search), emphasized the complementary nature of EPR spectroscopy within modern structural biology workflows. "Modern structural biology is moving towards integrating synergistic techniques to understand complex biomolecular systems. EPR spectroscopy adds an important layer of dynamic information that complements methods such as cryo-EM, NMR spectroscopy, and computational modeling."
Technology Platform
The FATHOM® EPR (search) spectroscopy platform represents a quantum-enabled approach to studying protein (search) dynamics, addressing the growing need to understand how proteins behave in motion rather than just their static structures. This technology is particularly valuable for investigating complex biological systems where traditional structural methods may fall short.
Creative Biostructure (search) provides structural biology services including cryo-EM, NMR spectroscopy, X-ray crystallography, membrane protein (search) characterization, and structure-based drug discovery support, supporting global research organizations in protein structure determination and molecular characterization across a range of therapeutic areas.