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ICAHN School of Medicine At Mount Sinai

ICAHN School of Medicine At Mount Sinai logo
🇺🇸United States
Ownership
Private, Subsidiary
Established
1963-01-01
Employees
5K
Market Cap
-
Website
http://www.mssm.edu
mskcc.org
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New AI Tool Uses Routine Blood Tests to Predict Immunotherapy Response for Many Cancers

SCORPIO, an AI model developed by MSK and Mount Sinai researchers, predicts cancer patients' response to immune checkpoint inhibitors using routine blood tests and clinical data, outperforming current FDA-approved biomarkers. It aims for equitable, cost-effective access to personalized cancer therapy.
nature.com
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Prediction of checkpoint inhibitor immunotherapy efficacy for cancer using routine blood

The study protocol was approved by institutional review boards, with informed consent from all patients. A real-world cohort of 3,278 patients treated with ICI from 2014-2019 was analyzed, excluding certain patients, resulting in 2,035 patients across 17 cancer types. Clinical and demographic data were collected, with missing values imputed. Machine learning models were constructed to predict clinical benefit and overall survival, using feature selection and ensemble models. The study also compared the prognostic performance of machine learning models with TMB and PD-L1, and analyzed bulk RNA-seq data for immune cell composition.
med.stanford.edu
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Blood test can predict how long vaccine immunity will last, Stanford Medicine-led study shows

Researchers identified a molecular signature in platelets linked to vaccine durability, suggesting megakaryocytes in bone marrow support plasma cell survival, enhancing antibody response. This discovery could lead to predictive tests for vaccine longevity and personalized vaccination strategies.
icahn.mssm.edu
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Institute for Transformative Clinical Trials

The Institute for Transformative Clinical Trials aims to improve health outcomes by conducting innovative clinical trials. It focuses on generating evidence for therapeutic interventions, enhancing clinical practice, and addressing public health questions. The Institute collaborates with researchers and the private sector to design and conduct trials, aiming to reduce healthcare disparities and influence policy.
drugstorenews.com
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FDA approves Celltrion's Stelara biosimilar

FDA approved Celltrion 's Steqeyma , a biosimilar to Johnson & Johnson 's Stelara , for treating plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. Steqeyma joins Celltrion USA 's immunology portfolio, enhancing treatment options for chronic inflammatory conditions.
pharmabiz.com
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New clinical practice guideline on process for diagnosing Alzheimer's disease or a related dementia

New guidelines for evaluating cognitive impairment or dementia due to Alzheimer’s or related diseases emphasize a three-step diagnostic formulation to inform care plans. They advocate for timely, accurate diagnosis, incorporating patient and care partner involvement, and utilizing advanced diagnostic tests to improve outcomes across clinical settings.
turan.az
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Pig kidney transplants, new schizophrenia drug: Here are 5 of the biggest medical

2024 saw significant medical breakthroughs, including gene therapy restoring hearing in children with hereditary deafness, the first genetically-edited pig kidney transplant into a human, discovery of a cause of lupus and potential reversal, FDA approval of the first new class of schizophrenia drug in over 30 years, and authorization of the first over-the-counter combo flu and COVID-19 test outside of emergency use.

Pig kidney transplants, new schizophrenia drug: Here are 5 of the biggest medical breakthroughs

2024 saw significant medical breakthroughs, including gene therapy restoring hearing in children, the first genetically-edited pig kidney transplant into a human, discovery of a lupus cause, FDA approval of the first new schizophrenia drug class in over 30 years, and the first over-the-counter COVID-19 and flu test outside of emergency use.
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