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LLMs Show Limited Benefit in Enhancing Physician Diagnostic Reasoning: A Randomized Trial

• A randomized clinical trial assessed whether large language models (LLMs) improve diagnostic reasoning among family, internal, and emergency medicine physicians. • The study found that LLM use did not significantly enhance diagnostic reasoning compared to conventional resources alone, with a non-significant 2% score difference. • The LLM alone outperformed both physician groups, scoring 16% higher than those using conventional resources, highlighting potential for AI in diagnostics. • Further development is needed to effectively integrate LLMs into clinical practice to improve physician-AI collaboration and diagnostic accuracy.
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