UNC Researchers Lead Groundbreaking HIV Clinical Trials in Vietnam
• UNC researchers Vivian Go and Dr. Bill Miller are conducting multiple clinical trials in Vietnam, focusing on HIV care retention and prevention strategies for high-risk populations.
• A recent study demonstrated that clinics using tailored support systems showed better implementation of HIV counseling interventions compared to standard approaches.
• Four ongoing trials are investigating new tuberculosis prevention drugs, hepatitis B vaccines for HIV patients, and interventions for alcohol reduction in HIV-positive individuals.
Red Blood Cell-Derived Nanocarriers Deliver Targeted Therapy for Drug-Resistant Lung Cancer
• Researchers have repurposed red blood cell-derived extracellular vesicles (EVs) as nanocarriers to deliver antisense oligonucleotides (ASOs) to lung cancer cells.
• The ASO-loaded EVs are engineered to target mutant Epidermal Growth Factor Receptors (EGFRs), a common driver of lung cancer, particularly in Asian populations.
• This targeted approach effectively suppresses cancer progression, even in tyrosine kinase inhibitor (TKI)-resistant cells, while sparing normal tissues.
• The study demonstrates a significant step towards personalized cancer medicine by customizing treatments based on individual patient cancer profiles.
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