• The NIH has initiated clinical trials under the RECOVER initiative to assess potential treatments for long COVID symptoms, addressing a significant unmet medical need.
• The RECOVER-VITAL trial will investigate the efficacy of Paxlovid in treating persistent SARS-CoV-2, while RECOVER-NEURO will explore interventions for cognitive dysfunction, including brain fog.
• Additional trials, RECOVER-SLEEP and RECOVER-AUTONOMIC, will address sleep disturbances and autonomic nervous system dysfunction, respectively, with plans for an exercise and fatigue study.
• These trials represent a crucial step in the comprehensive effort to understand, treat, and prevent long COVID, with the aim of informing clinical care and improving patient outcomes.