Yeungnam University College of Medicine

Korean researchers identified preoperative topical glaucoma medication exposure, quantified by the Glaucoma Medication Intensity Index (GMII), as a significant risk factor for trabeculectomy failure in primary open-angle glaucoma (POAG) patients. Advanced age at surgery and subsequent cataract surgery also increased failure risk. A GMII threshold of ≥4.35 was linked to poorer long-term intraocular pressure (IOP) control. The study suggests optimizing surgery timing to minimize GMII exposure could improve outcomes.