A randomized open-label multicenter trial in Denmark compared BiliCocoon to overhead phototherapy for neonates with TSB above treatment limit. 85 neonates were randomized, 44 to BiliCocoon and 41 to overhead phototherapy. Treatment duration was 24h, with continuous phototherapy for BiliCocoon and intermittent breaks for overhead. Irradiance levels were measured and adjusted, with BiliCocoon showing a homogeneous distribution and overhead light highest centrally. TSB and hemoglobin were measured before and after treatment to assess efficacy.