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C4 Therapeutics

πŸ‡ΊπŸ‡ΈUnited States
Ownership
-
Employees
145
Market Cap
$445.8M
Website
Introduction

C4 Therapeutics, Inc. engages in the development of targeted protein degradation science to develop a new generation of small molecule medicines used for treating diseases. It develops the Degronimid platform that incorporates small molecule binders to target disease-causing proteins and facilitate their destruction and clearance from the cell through the natural ubiquitin and proteasome system. The company was founded by James E. Bradner, Kenneth C. Anderson, Nathanael S. Gray and Marc A. Cohen in October 2015 and is headquartered in Watertown, MA.

A Study to Characterize the Safety, Tolerability, and Preliminary Efficacy of CFT1946 as Monotherapy and Combination Therapy in Subjects With BRAF V600 Mutant Solid Tumors

Phase 1
Active, not recruiting
Conditions
Solid Tumors
Melanoma
NSCLC
CRC
ATC
Interventions
First Posted Date
2022-12-30
Last Posted Date
2025-05-13
Lead Sponsor
C4 Therapeutics, Inc.
Target Recruit Count
89
Registration Number
NCT05668585
Locations
πŸ‡ΊπŸ‡Έ

University of Arizona - Cancer Center, Tucson, Arizona, United States

πŸ‡ΊπŸ‡Έ

Florida Cancer Specialists, Sarasota, Florida, United States

πŸ‡ΊπŸ‡Έ

Community Health Network, Indianapolis, Indiana, United States

and more 23 locations

A Study to Assess the Safety and Tolerability of CFT8634 in Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors

Phase 1
Terminated
Conditions
Synovial Sarcoma
Soft Tissue Sarcoma
Interventions
First Posted Date
2022-05-02
Last Posted Date
2024-12-17
Lead Sponsor
C4 Therapeutics, Inc.
Target Recruit Count
49
Registration Number
NCT05355753
Locations
πŸ‡ΊπŸ‡Έ

City of Hope, Duarte, California, United States

πŸ‡ΊπŸ‡Έ

Sarcoma Oncology Research Center, Santa Monica, California, United States

πŸ‡ΊπŸ‡Έ

University of Colorado - Aurora Cancer Center, Aurora, Colorado, United States

and more 9 locations

Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma

Phase 1
Recruiting
Conditions
Multiple Myeloma
Lymphoma, Non-Hodgkin's
Interventions
First Posted Date
2021-02-16
Last Posted Date
2024-08-28
Lead Sponsor
C4 Therapeutics, Inc.
Target Recruit Count
224
Registration Number
NCT04756726
Locations
πŸ‡ΊπŸ‡Έ

Mayo Clinic, Rochester, Minnesota, United States

πŸ‡ΊπŸ‡Έ

University of California-San Francisco, San Francisco, California, United States

πŸ‡ΊπŸ‡Έ

Colorado Blood Cancer Institute (Sarah Cannon Research Institute), Denver, Colorado, United States

and more 8 locations
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