Fox Chase Trial Explores Active Surveillance for Muscle-Invasive Bladder Cancer
• The RETAIN Bladder study investigates active surveillance as an alternative to total bladder removal for muscle-invasive bladder cancer (MIBC) patients responding to chemotherapy.
• The trial employs a risk-adapted approach, utilizing clinical features and genetic mutations to predict chemotherapy effectiveness and tailor treatment recommendations.
• Researchers aim to identify biomarkers that predict response to chemotherapy, potentially allowing some patients to avoid cystectomy and preserve bladder function.
• The study assesses metastasis-free survival, bladder preservation rates, quality of life, and genomic correlates to refine bladder cancer treatment strategies.
© Copyright 2025. All Rights Reserved by MedPath