C. Michael Gibson discovered high lipoprotein(a) levels, inherited from his grandfather, despite decent cholesterol. Research is ongoing for medications to lower lipoprotein(a) and other approaches to reduce cardiovascular disease risk. Statins are effective but not sufficient, prompting exploration of new treatments targeting various cholesterol types, including HDL and remnant cholesterol. Clinical trials are underway, with mixed results so far, but optimism remains for potential breakthroughs.