CELGENE CORPORATION

The Red Biotechnology Market, valued at USD 492.71 billion in 2023, is projected to reach USD 997.42 billion by 2032, driven by increasing R&D spending and advancements in genomics. Key players include Merck, F. Hoffmann-La Roche AG, and Pfizer. The market focuses on medical and pharmaceutical applications, including drug discovery and genetic modification, with growth opportunities in personalized medicine and AI integration. Challenges include regulatory and ethical concerns.

Mirikizumab (Omvoh) showed improved outcomes in Crohn's disease patients with previous standard therapy failure, with 38% meeting composite endpoint of PRO clinical response at week 12 and endoscopic response at week 52 vs. 9% on placebo (P<0.0001). Mirikizumab also met primary endpoint of PRO clinical response at week 12 and CDAI clinical remission at week 52 in 45.4% vs. 19.6% on placebo (P<0.0001). The study highlights IL-23's role in Crohn's disease pathogenesis and suggests mirikizumab's favorable benefit-risk profile.

The Gene Switch Market is projected to grow from USD 0.78 Bn in 2024 to USD 1.78 Bn by 2031, with a CAGR of 11.6%. CoherentMI's report provides a comprehensive analysis of market trends, competitive landscape, and key players like Novartis, Pfizer, and Gilead Sciences.

DelveInsight's 'Crohn's Disease Pipeline Insight, 2024' report details 70+ companies developing 80+ therapies, including AstraZeneca, Immunic, Suzhou Connect Biopharmaceuticals, Pfizer, and Bristol-Myers Squibb. Key therapies like MORF 057, OTL-104, TP-317, AZD 7798, IMU 856, CBP-307, PF-06651600, Deucravacitinib, E6011, Guselkumab, Mirikizumab, Filgotinib, RHB-104, Ozanimod, and Brazikumab are expected to impact the market. The report covers clinical trials, regulatory approvals, market dynamics, and therapeutic assessments by route of administration and molecule type.

DelveInsight's report on Crohn’s Disease Market Insights, Epidemiology, and Market Forecast-2034 details the market size, emerging therapies, and key companies like Takeda Pharmaceutical, Janssen Pharmaceuticals, UCB, Biogen, AbbVie, AstraZeneca, Tillotts Pharma, Gilead Sciences, Galapagos NV, Boehringer Ingelheim, Celgene (Bristol Myers Squibb), Eli Lilly and Company, RedHill Biopharma, Arena Pharmaceuticals, Mesoblast, and others. The market size in 7MM was ~USD 9,000 million in 2023, expected to increase by 2034, with key therapies like ENTYVIO, STELARA, VELSIPITY, Zeposia, LY-3074828, RHB-104, and others expected to launch. Positive results for mirikizumab and TREMFYA were reported in 2024, and Dong-A-ST's Imuldosa received FDA approval as a biosimilar to Stelara.

The neurodegenerative disorder therapeutics market is projected to grow from $18.53 billion in 2023 to $28.33 billion in 2028 at a CAGR of 9.0%, driven by factors like aging population, rising prevalence of neurodegenerative disorders, and strategic collaborations among pharmaceutical companies.

The non-small cell lung cancer market is driven by increasing NSCLC cases, uptake of immune checkpoint inhibitors, emerging premium therapies, and awareness of mutations. DelveInsight's report covers current treatment practices, emerging drugs, market share, and forecasted market size from 2019 to 2032 in 7MM. Key companies and therapies include EMD Serono, Merck, AstraZeneca, Bristol-Myers Squibb, and therapies like M1774, C-TIL051, and Osimertinib. FDA approvals for Opdivo and Tagrisso in 2024 highlight advancements in treatment.

Cabaletta Bio reports Q3 2024 financial results, with $183M in cash, cash equivalents, and short-term investments, supporting operations into H1 2026. Clinical data from RESET-Myositis™, RESET-SLE™, and initial RESET-SSc™ trials to be presented at ACR Convergence 2024. 16 patients enrolled, 10 dosed in the RESET™ program, with 40 U.S. clinical sites actively recruiting. Plans to meet with FDA in 2025 for potential registrational program designs for CABA-201. Clinical development expands into Europe with EMA CTA authorization for CABA-201 in lupus; Gerwin Winter appointed as Senior VP and Head of International.

Cabaletta Bio reported Q3 2024 financial results and business updates, with 40 U.S. clinical sites actively recruiting patients across its RESET clinical trials, 16 enrolled and 10 dosed as of November 12. Clinical data from RESET-Myositis, RESET-SLE, and initial data from RESET-SSc trials will be presented at ACR Convergence 2024. The company received EMA CTA authorization for CABA-201 in lupus, expanding into Europe. Cash position stands at $183.0 million as of September 30, 2024, expected to fund operations into first half of 2026.

J.P.-G. consults for Lilly, Roche, Eisai, Daiichi Sankyo, AstraZeneca, Seattle Genetics, Gilead, MSD; receives travel compensation from Roche; employed by MEDSIR. G.A. receives honoraria from MEDSIR. M.G. receives travel support and honoraria from AstraZeneca, Gilead Sciences, Roche, Pfizer. A.L.-C. receives research support, consults, speaks, and travels for Roche, Lilly, Pfizer, Novartis, Merck Sharp & Dohme, Gilead, Daiichi Sankyo; owns MEDSIR, Initia-Research. J.C. consults, receives honoraria, research funding, stock, travel expenses, and patents for Roche, Celgene, Cellestia, AstraZeneca, Seattle Genetics, Daiichi Sankyo, Erytech, Athenex, Polyphor, Lilly, Merck Sharp & Dohme, GSK, Leuko, Bioasis, Clovis Oncology, Boehringer Ingelheim, Ellipses, HiberCell, BioInvent, GEMoaB, Gilead, Menarini, Zymeworks, Reveal Genomics, Expres2ion Biotechnologies; holds patents for pharmaceutical combinations.