The Christie NHS Foundation Trust

A 69-year-old man from Stockport shows no cancer signs 6 years after joining the FLAIR trial at The Christie NHS Foundation Trust. The trial tested if targeted drugs (venetoclax and ibrutinib) were more effective than chemotherapy for untreated chronic lymphocytic leukaemia (CLL). Results showed improved survival and remission rates, with fewer side effects compared to chemotherapy. The trial, led by the University of Leeds, involved 1500 participants across 100 UK hospitals and was funded by Cancer Research UK, Janssen, and AbbVie.

Sheffield Teaching Hospitals NHS Foundation Trust launches a 'matchmaking' service offering bowel cancer patients personalised 'vaccines' from their DNA mutations, aiming to prevent cancer recurrence. The Cancer Vaccine Launch Pad plans to recruit thousands across England for immunotherapy trials, initially focusing on colorectal cancer patients with surgically removed tumours and detectable ctDNA.

The world’s largest clinical trial using radiotherapy for metastatic lung cancer, sponsored by The Christie NHS Foundation Trust, aims to recruit nearly 1,000 stage IV NSCLC patients. Funded by a £3.4 million grant from NIHR, the study seeks to improve quality of life and extend life expectancy, potentially impacting global clinical practice.

Elaine Sleigh, a breast cancer patient, saw her tumours decrease by 65% due to research at The Christie NHS Foundation Trust. After initial treatment, she joined a trial for a new blood test to detect cancer cell DNA in the bloodstream. When cancer recurred, she participated in the PETRA trial, receiving a combination of targeted chemotherapy and an experimental drug, AZD5305, which is a PARP inhibitor. Elaine's condition improved, and she attributes her progress to the trials and positive attitude.

Mike Peters, frontman of The Alarm, diagnosed with aggressive Richter’s syndrome, saw his cancer disappear after participating in a clinical trial combining acalabrutinib with chemotherapy at The Christie NHS Foundation Trust. Now in complete remission, he plans to undergo a donor stem cell transplant for a chance at a cure.

The Alarm's Mike Peters is in remission from aggressive cancer after an NHS drug trial. He now seeks a stem cell donor for a transplant to prevent recurrence.