In 2024, significant advancements were made in addiction research, highlighting the hijacking of brain reward systems by drugs, structural brain changes in opioid use disorder, declining adolescent substance use, ketamine's antidepressant effects, challenges in alcohol use disorder treatment, comparative effectiveness of buprenorphine/naloxone vs. methadone, the impact of parental drug overdose on children, potential of GLP-1 receptor agonists for alcohol use disorder, promise of anti-fentanyl vaccines, and surveillance of new psychoactive substances.