Prior Dengue Infection Linked to Increased Risk of Severe Dengue, Meta-Analysis Shows
• A meta-analysis of phase III trials reveals that prior dengue infection reduces the risk of virologically confirmed dengue in subsequent infections.
• The study indicates a significantly higher risk of developing severe dengue in individuals with a history of dengue infection compared to those without.
• Researchers found no significant impact of prior dengue infection on dengue hospitalization, dengue-related death, or all-cause mortality.
• Findings suggest a need to reconsider prior infection as an independent risk factor in dengue severity and outcomes.
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