University of Salerno

The article highlights tissue engineering as a promising approach for articular cartilage repair, using 3D scaffolds and bioengineered supports to stimulate cartilage regeneration. It discusses recent advancements in 3D in vitro models, organoids, and the role of microRNAs in mitigating inflammation and fibrosis. The article also explores bibliometric analysis of joint distraction treatments for osteoarthritis and the use of 3D printing technology for fabricating biocompatible scaffolds for osteochondral defects treatment.

AI revolutionizes drug discovery and development, accelerating research, reducing costs, and increasing the probability of drug success in Phase 2 clinical trials. AI tools, including generative AI, enable rapid exploration of chemical spaces and multi-objective optimization of drug properties. AI-focused biotechs have already advanced several drug candidates into clinical trials in record time. AI also enhances clinical trial operations and regulatory affairs, promising faster, cheaper, and better-value drug development. The second part of the series will explore the financial benefits and the impact on the Probability of Success (PoS) in Phase 2 trials.