A study finds significant disparities in Americans' well-being by region, with the lowest scores in the southern U.S., Appalachia, and Rust Belt states, and the highest in Colorado, Maryland, New York, California, Virginia, and Washington, D.C. The Human Development Index (HDI) shows an overall U.S. increase from 2008 to 2019, then a decline in 2020 due to COVID-19. White men represent the largest group with the lowest well-being, while Asian American women have the longest life expectancy. The study calls for targeted social programs to address structural inequalities.