The global OTC drug and dietary supplement market was valued at $310.96 billion in 2023, expected to reach $438.25 billion by 2028, and $632.1 billion by 2033. Factors driving growth include health consciousness, dietary supplement demand, government initiatives, aging population, and e-commerce expansion. Key segments include vitamin and dietary supplements, tablets, and pharmacies. North America leads the market, with Asia-Pacific and Africa expected to grow fastest.