AstraZeneca

AstraZeneca logo
🇬🇧United Kingdom
Ownership
Public
Employees
89.9K
Market Cap
$270.3B
Website
http://www.astrazeneca.co.uk
Introduction

AstraZeneca Plc is a holding company, which engages in the research, development, manufacture, and commercialization of prescription medicines. The company was founded on June 17, 1992 and is headquartered in Cambridge, the United Kingdom.

jobs.biobuzz.io
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Senior Director, Transactions - Oncology R&D in Gaithersburg, Maryland

AstraZeneca seeks a Senior Director, Business Development Transactions - Oncology R&D to lead transactions, enrich capabilities through external innovation, and contribute to the business development strategy. The role requires a Bachelor’s degree, 5+ years in life sciences, and experience in business development, licensing, or commercial roles. The position offers a base salary range of $187,000-$280,000 and is based in Gaithersburg, MD or Waltham, MA.
cen.acs.org
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Thinking on linkers for antibody-drug conjugates

Linker chemistry in antibody-drug conjugates (ADCs) plays a crucial role in cancer therapies, determining payload release and efficacy. Despite 11 FDA-approved ADCs and 266 clinical trials, the complexity of linkers remains a challenge, influencing ADC stability, toxicity, and target specificity. Innovations like PEG linkers and click chemistry aim to enhance ADC performance, but the field still lacks definitive rules for optimal linker design.
nature.com
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GLP1 agonists: current and future landscape of clinical trials for patients with metabolic dysfunction

M.J.D. has consulted, advised, and spoken for Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Sanofi, Pfizer, AstraZeneca, Zealand Pharma, Carmot/Roche, and Amgen. She has also received grants from AstraZeneca, Novo Nordisk, Boehringer Ingelheim, Janssen, Sanofi-Aventis, and Eli Lilly. J.G. has no competing interests.

Researchers Aim to Confirm Benefits of Non-Hormonal Therapy for Certain Prostate Cancer Patients

A Phase II trial showed AstraZeneca's Lynparza (olaparib) effective in treating recurrent prostate cancer without hormone therapy, prompting larger follow-up studies in biomarker-selected subgroups. Lynparza, a PARP inhibitor, demonstrated efficacy in patients with homologous recombination repair gene mutations, particularly BRCA2, with higher response rates than seen with hormonal suppression. The study suggests that not all prostate cancer patients need hormone therapy and highlights the need for biomarker-selected trials to identify responders.
genengnews.com
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Animal Models Aren't Human!

Animal models and traditional in vitro assays have limitations in drug development, leading to the adoption of Organ-on-a-chip (OOC) technology. Two case studies illustrate how human OOC models resolved conflicting animal data, guiding safer drug development and reducing animal use. Early integration of human and animal OOC systems can refine preclinical study design and de-risk first-in-human studies.
openpr.com
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Biotechnology Market: CAGR of 14.2% Trends, Share Metrics

The Global Biotechnology Market, valued at USD 1,094.6 Billion in 2024, is projected to reach USD 2772.7 Billion by 2032, with a CAGR of 14.2%. The market report includes detailed analysis, key players, and segments such as applications and technologies, with regional assessments covering North America, Europe, Asia Pacific, Latin America, and Middle East and Africa.
prnewswire.com
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Major Release of Veeva Site Connect Streamlines Clinical Trial Execution for Sites and Sponsors

Veeva Systems announces Veeva Site Connect, enhancing sponsor-site collaboration with new capabilities and a streamlined experience, reducing trial time and cost. Seven top 20 biopharmas have adopted the platform for simplified trial execution.
astrazeneca.com
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AstraZeneca advances ambition to improve standards of care in multiple cancer types

The article presents various studies on antibody drug conjugates, including datopotamab deruxtecan (Dato-DXd) and trastuzumab deruxtecan (T-DXd), in different cancer types such as endometrial, ovarian, breast, lung, and gastric cancers. It also covers studies on immuno-oncology treatments like durvalumab and neoadjuvant strategies, as well as initial results from first-in-human studies of new antibody-drug conjugates like AZD8205 and AZD5335. Additionally, it discusses the role of circulating tumor DNA (ctDNA) dynamics in treatment responses and long-term survival outcomes in various cancer settings.
hcplive.com
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Common Pitfalls to Avoid When Interpreting Clinical Trials, with Deepak Bhatt, MD, MPH, MBA

Deepak Bhatt, a prominent cardiologist, discussed common pitfalls in interpreting clinical trial data at the ESC Congress 2024. His work, cited over 275,000 times, focuses on pivotal trials like REDUCE-IT and SCORED. Bhatt highlighted the 17-year lag between scientific discovery and its adoption into clinical practice.
drughunter.com
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An Oral Small Molecule PCSK9 Inhibitor Disclosed by AstraZeneca

Nurix Therapeutics' NX-1607, an oral CBL-B inhibitor, is in clinical trials to enhance T cell activation, addressing limitations of immune checkpoint inhibitors. Initial results presented at ACS Spring 2024.
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