AstraZeneca

CALQUENCE plus venetoclax with obinutuzumab reduced the risk of disease progression or death by 58% versus standard-of-care chemoimmunotherapy in previously untreated adult patients with chronic lymphocytic leukemia (CLL). CALQUENCE plus venetoclax demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) compared to standard-of-care chemoimmunotherapy.

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AMPLIFY Phase III trial results show AstraZeneca's Calquence in combination with venetoclax significantly improves progression-free survival in untreated chronic lymphocytic leukaemia patients compared to standard-of-care chemoimmunotherapy, with a 35% reduction in disease progression or death risk. The trial will continue to assess overall survival as a key secondary endpoint.

AMPLIFY trial interim analysis shows acalabrutinib plus venetoclax with or without obinutuzumab significantly improves progression-free survival (PFS) in untreated chronic lymphocytic leukemia (CLL) compared to standard-of-care chemoimmunotherapy, with median PFS not reached in the acalabrutinib plus venetoclax arms and 47.6 months in the SOC arm. The combination reduced the risk of disease progression or death by 35% for the doublet and 58% for the triplet regimen.

Acalabrutinib plus venetoclax, with or without obinutuzumab, significantly improved progression-free survival (PFS) in treatment-naive chronic lymphocytic leukemia (CLL) patients compared to standard-of-care chemoimmunotherapy, according to the AMPLIFY trial. The 36-month PFS rates were 83.1% and 76.5% with the combinations, versus 66.5% with SOC. The triplet regimen showed better PFS, especially for patients with unmutated IGHV, and higher undetectable minimal residual disease rates.

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CALQUENCE plus venetoclax with obinutuzumab reduced the risk of disease progression or death by 58% versus standard of care in previously untreated adult patients with chronic lymphocytic leukemia (CLL). CALQUENCE plus venetoclax demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) compared to standard-of-care chemoimmunotherapy.

CALQUENCE safety consistent with known profile; no new safety signals. Grade 3+ AEs: 53.6% (CALQUENCE + venetoclax), 69.4% (with obinutuzumab), 60.6% (chemoimmunotherapy). Most common Grade 3+ AE: neutropenia. Low TLS rates observed in CALQUENCE arms (0.3% and 0.4%) vs. 3.1% (chemoimmunotherapy). No clinical TLS cases. CALQUENCE used in >85,000 patients worldwide; approved for CLL/SLL in US, Japan, EU, China.