AstraZeneca and Amgen's Tezspire (tezepelumab) met co-primary endpoints in a Phase III trial for chronic rhinosinusitis with nasal polyps, showing significant reduction in nasal polyp size and congestion. The therapy, a TSLP inhibiting monoclonal antibody, previously received FDA approval for severe asthma and a breakthrough therapy designation for COPD. Tezspire's main competitor is Sanofi and Regeneron's Dupixent, which also treats CRSwCP and other immune-mediated disorders.