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UK Clinical Trial Aims to Resolve Debate on Puberty Blockers for Gender Dysphoria

• A clinical trial is being planned in the UK to evaluate the benefits and harms of puberty blockers for young people with gender dysphoria. • The trial aims to address the lack of high-quality evidence on the long-term effects of puberty blockers on mental health, brain development, and bone density. • Ethical concerns are being debated, including whether it is ethical to withhold puberty blockers from some participants or to use a placebo group. • The trial design is complex, with considerations for different intervention approaches and the inclusion of psychological and emotional support.
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