UNIVERSITY OF CINCINNATI

Researchers have discovered that AM-101, a synthetic benzodiazepine analog, can enhance the efficacy of radiation therapy for lung cancer that has metastasized to the brain.

A recent study identifies progesterone, specifically Provera, as a significant risk factor for vision loss related to meningiomas in premenopausal women.

• New research suggests Alzheimer's drugs like lecanemab and donanemab may slow disease progression by increasing levels of healthy amyloid beta (Aβ42) protein in the brain. • The study challenges the prevailing theory that these drugs work solely by reducing toxic amyloid plaques, highlighting the potential importance of soluble Aβ42 in maintaining brain health. • Researchers analyzed data from nearly 26,000 patients, finding that increased levels of soluble Aβ42 correlated with slower Alzheimer's progression during treatment with these monoclonal antibodies. • The study authors propose alternative therapies focused on boosting soluble Aβ42 levels directly, rather than solely targeting amyloid plaques, which may have long-term risks.