UNIVERSITY OF CINCINNATI

Pooja Khatri, MD, MS, has been appointed chair of the Department of Neurology and chief of neurology at Yale New Haven Hospital and Yale New Haven Health System, effective April 1, 2025. Dr. Khatri, currently at the University of Cincinnati, is an internationally recognized expert in clinical stroke with extensive research and leadership experience.

Lomond Therapeutics announced Phase 1 clinical study results of lonitoclax, a BCL-2 inhibitor, showing no significant safety issues and improved selectivity over venetoclax. Lonitoclax demonstrated robust inhibition of BCL-2 without altering exposures when co-administered with itraconazole, highlighting its potential for outpatient treatment in CLL and AML.

Lungpacer Medical's AeroPace System, an FDA-approved neurostimulation therapy, aims to strengthen the diaphragm for quicker weaning from mechanical ventilation, offering faster recovery, reduced ventilator days, and lower reintubation risk.

Mission Bio announces 20+ presentations at ASH 2024 showcasing Tapestri Platform's impact on hematology, including new datasets on Multiple Myeloma, AML, and CAR-T therapy development.

Pregnancy challenges for women with epilepsy include medication risks like valproate's link to autism and lower IQ, and the need for dose adjustments due to faster metabolism. A study followed 298 children of women with epilepsy to age 6, finding no difference in verbal abilities compared to healthy women's children, though medication levels in the third trimester had nuanced effects. Folate supplementation was beneficial, while acetaminophen showed risks. Further research is needed to understand the long-term effects of various epilepsy drugs and genetic factors influencing outcomes.

UC Cancer Center explores personalized mRNA vaccines to reduce lung cancer recurrence, developed from patients' surgically removed tumors combined with immunotherapy. Clinical trials aim to prevent cancer recurrence by targeting individual cancer vulnerabilities, potentially leading to broader preventative vaccines.

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UC's Yasmin Aziz and Joseph Broderick analyze alternatives to traditional informed consent in acute stroke trials, emphasizing the need for emergency consent due to time constraints and patient incapacitation. They discuss the challenges and ongoing efforts to make exception from informed consent (EFIC) protocols more efficient and less costly, while maintaining patient autonomy and beneficence.

Miami University researcher Andrew Jones uses bioreactors to produce psilocybin and other psychedelics, attracting attention and funding. Despite FDA setbacks like rejecting Lykos Therapeutics' MDMA application, interest in psychedelics for treating PTSD, depression, and addiction remains high. Jones' lab synthesizes compounds for consistency and safety, and he collaborates on research into psilocybin's neuroplastic and anti-inflammatory effects. Public acceptance of psychedelics is growing, with legal psilocybin therapy available in Oregon, and ongoing research worldwide.

Science cafés, popular since their inception in France and the UK over 25 years ago, aim to make science accessible through relaxed public interactions. These events, often free, feature brief expert talks followed by Q&A sessions, with topics chosen based on community feedback. NIEHS-funded centers at the University of Arizona, Cincinnati, and Iowa have created such cafés to engage communities, share research, and address local environmental health concerns.