Western History Collection

Novel Hafnium-Based Treatment Trial Launches for Cisplatin-Ineligible Head and Neck Cancer Patients

3 months ago

• International researchers launch NANORAY-312 trial investigating hafnium metal therapy combined with radiation as a novel treatment approach for head and neck cancer patients unsuitable for cisplatin treatment. • Recent Lancet study reveals durvalumab immunotherapy failed to outperform cetuximab when combined with radiation therapy, highlighting the ongoing challenge in finding alternatives to cisplatin. • University of Oklahoma joins 160 global sites in testing innovative hafnium-based approach designed to enhance radiation effectiveness while preserving healthy tissue.

PROSPECT-Lung Trial Investigates Optimal Timing of Immunotherapy in Non-Small Cell Lung Cancer

5 months ago

• The PROSPECT-Lung trial is evaluating whether immunotherapy is more effective when administered before or after surgery for resectable non-small cell lung cancer. • This pragmatic trial aims to reflect real-world treatment decisions and provide clearer guidance on integrating immunotherapy into lung cancer treatment regimens. • The study will enroll 1,100 patients across multiple sites in the United States and is led by the Alliance for Clinical Trials in Oncology and the SWOG Cancer Research Network. • PROSPECT-Lung is the first trial to open through the NCI's Clinical Trials Innovation Unit, designed to accelerate cancer treatment development.

Route 66 SPORE Grant to Study Non-Surgical Treatments for Uterine Cancer

8 months ago

• The UNM Cancer Center is launching a clinical trial as part of the Route 66 SPORE grant to explore non-surgical treatments for uterine cancer, aiming to preserve fertility in younger women. • The trial seeks to identify biomarkers that predict response to hormone therapy, potentially allowing doctors to personalize treatment approaches for women with early-stage uterine cancer. • The study will also investigate the impact of intensive exercise and diet control on uterine cancer treatment outcomes, integrating lifestyle interventions into the therapeutic strategy. • The Route 66 SPORE projects will involve over 100 women across three institutions, with a three-year follow-up to assess the long-term efficacy of non-surgical interventions.