Researchers from Leipzig University and TU Dresden have made a breakthrough in separating hydrogen isotopes (protium, deuterium, tritium) at room temperature, potentially reducing costs and energy consumption. Their findings, published in Chemical Science, detail the influence of framework environment on binding selectivity, enabling targeted optimization of materials for high selectivity. Funded by the German Research Foundation, the 1,2,3H Research Training Group aims to develop novel materials and more effective drugs through hydrogen isotope research.